A stem cell population at the anorectal junction maintains homeostasis and participates in tissue regeneration

Louciné Mitoyan; Véronique Chevrier; Hector Hernandez-Vargas; Alexane Ollivier; Zeinab Homayed; Julie Pannequin; Flora Poizat; Cécile De Biasi-Cador; Emmanuelle Charafe-Jauffret; Christophe Ginestier; Géraldine Guasch

doi:10.1038/s41467-021-23034-x

Nature Communications (May 2021)

A stem cell population at the anorectal junction maintains homeostasis and participates in tissue regeneration

Louciné Mitoyan,
Véronique Chevrier,
Hector Hernandez-Vargas,
Alexane Ollivier,
Zeinab Homayed,
Julie Pannequin,
Flora Poizat,
Cécile De Biasi-Cador,
Emmanuelle Charafe-Jauffret,
Christophe Ginestier,
Géraldine Guasch

Affiliations

Louciné Mitoyan: Aix-Marseille University, CNRS, INSERM, Institut Paoli-Calmettes, CRCM, Epithelial Stem Cells and Cancer Team
Véronique Chevrier: Aix-Marseille University, CNRS, INSERM, Institut Paoli-Calmettes, CRCM, Epithelial Stem Cells and Cancer Team
Hector Hernandez-Vargas: Department of Immunity, Virus and Inflammation, Cancer Research Center of Lyon (CRCL), Inserm U 1052, CNRS UMR 5286, Université de Lyon, Centre Léon Bérard
Alexane Ollivier: Aix-Marseille University, CNRS, INSERM, Institut Paoli-Calmettes, CRCM, Epithelial Stem Cells and Cancer Team
Zeinab Homayed: CNRS, UMR5203, Inserm U661, Institut de Génomique Fonctionnelle
Julie Pannequin: CNRS, UMR5203, Inserm U661, Institut de Génomique Fonctionnelle
Flora Poizat: Department of Biopathology, Institut Paoli-Calmettes
Cécile De Biasi-Cador: Department of Biopathology, Institut Paoli-Calmettes
Emmanuelle Charafe-Jauffret: Aix-Marseille University, CNRS, INSERM, Institut Paoli-Calmettes, CRCM, Epithelial Stem Cells and Cancer Team
Christophe Ginestier: Aix-Marseille University, CNRS, INSERM, Institut Paoli-Calmettes, CRCM, Epithelial Stem Cells and Cancer Team
Géraldine Guasch: Aix-Marseille University, CNRS, INSERM, Institut Paoli-Calmettes, CRCM, Epithelial Stem Cells and Cancer Team

DOI: https://doi.org/10.1038/s41467-021-23034-x
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 13

Abstract

Read online

Transition zones connect distinct epithelia, contain cells expressing stem cell markers, and contribute to cancer development. Here, the authors examine the mouse anorectal junction, identifying a population of Krt17-positive basal cells that contribute to squamous and glandular epithelia during homeostasis and repair.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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