Nature Communications (Jan 2022)

Heterotrimeric Gq proteins act as a switch for GRK5/6 selectivity underlying β-arrestin transducer bias

  • Kouki Kawakami,
  • Masataka Yanagawa,
  • Suzune Hiratsuka,
  • Misaki Yoshida,
  • Yuki Ono,
  • Michio Hiroshima,
  • Masahiro Ueda,
  • Junken Aoki,
  • Yasushi Sako,
  • Asuka Inoue

DOI
https://doi.org/10.1038/s41467-022-28056-7
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 16

Abstract

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GPCR kinases (GRKs) phosphorylate active-form G-protein-coupled receptors (GPCRs). Here, the authors reveal that Gq heterotrimer coupled with the angiotensin II type-1 receptor (AT1R) determines the GRK subtypes recruited to the complex in a microdomain, thus defining subsequent AT1R phosphorylation patterns, β-arrestin conformation and functionality.