INHIBITION OF CANCER CELL INVASION AND METASTASIS BY NF-KAPPA-B INHIBITORS (ИНГИБИРОВАНИЕ ИНВАЗИИ РАКОВЫХ КЛЕТОК И МЕТАСТАЗОВ ПРИ ПОМОЩИ ИНГИБИТОРОВ NF-КАППА-B)

Abstract

We designed a potent and specific NF-kappa-B inhibitor called dehydroxymethylepoxyquinomicin (DHMEQ), based on the structure of epoxyquinomicins, which are weak antibiotics isolated from Amicolatopsis. It is believed that inhibition of NFkappa -B may play a significant role in controlling the process of metastasis. We have therefore synthesized derivatives of about 20, of which DTCMglutarimide (DTCM-G). We have evaluated the antimetastatic activity of the preparation using murine melanoma B16-F10. It was found that DTCM-G inhibits cell invasion and induces anoikoz in cells B16-F10. This preparation is non-toxic and easy to manufacture. Thus , it can be considered as a new candidate for the antimetastatic drug.

Keywords

• nf-каппа-в
• dhmeq
• метастазирование
• противометастатическая активность
• аноикоз
• dtcm-глутаримид