IL-25 blockade augments antiviral immunity during respiratory virus infection

Teresa C. Williams; Su-Ling Loo; Kristy S. Nichol; Andrew T. Reid; Punnam C. Veerati; Camille Esneau; Peter A. B. Wark; Christopher L. Grainge; Darryl A. Knight; Thomas Vincent; Crystal L. Jackson; Kirby Alton; Richard A. Shimkets; Jason L. Girkin; Nathan W. Bartlett

doi:10.1038/s42003-022-03367-z

Communications Biology (May 2022)

IL-25 blockade augments antiviral immunity during respiratory virus infection

Teresa C. Williams,
Su-Ling Loo,
Kristy S. Nichol,
Andrew T. Reid,
Punnam C. Veerati,
Camille Esneau,
Peter A. B. Wark,
Christopher L. Grainge,
Darryl A. Knight,
Thomas Vincent,
Crystal L. Jackson,
Kirby Alton,
Richard A. Shimkets,
Jason L. Girkin,
Nathan W. Bartlett

Affiliations

Teresa C. Williams: The University of Newcastle and Hunter Medical Research Institute
Su-Ling Loo: The University of Newcastle and Hunter Medical Research Institute
Kristy S. Nichol: The University of Newcastle and Hunter Medical Research Institute
Andrew T. Reid: The University of Newcastle and Hunter Medical Research Institute
Punnam C. Veerati: The University of Newcastle and Hunter Medical Research Institute
Camille Esneau: The University of Newcastle and Hunter Medical Research Institute
Peter A. B. Wark: The University of Newcastle and Hunter Medical Research Institute
Christopher L. Grainge: The University of Newcastle and Hunter Medical Research Institute
Darryl A. Knight: The University of Newcastle and Hunter Medical Research Institute
Thomas Vincent: Abeome Corporation/Lanier Biotherapeutics
Crystal L. Jackson: Abeome Corporation/Lanier Biotherapeutics
Kirby Alton: Abeome Corporation/Lanier Biotherapeutics
Richard A. Shimkets: Abeome Corporation/Lanier Biotherapeutics
Jason L. Girkin: The University of Newcastle and Hunter Medical Research Institute
Nathan W. Bartlett: The University of Newcastle and Hunter Medical Research Institute

DOI: https://doi.org/10.1038/s42003-022-03367-z
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 13

Abstract

Read online

IL-25 and its receptor are expressed in airway epithelial cells of healthy individuals and patients with asthma and antibody-mediated blockade of IL-25 enhances antiviral immunity and blocks virus-exacerbated asthma responses.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal