MANF antagonizes nucleotide exchange by the endoplasmic reticulum chaperone BiP

Yahui Yan; Claudia Rato; Lukas Rohland; Steffen Preissler; David Ron

doi:10.1038/s41467-019-08450-4

Nature Communications (Feb 2019)

MANF antagonizes nucleotide exchange by the endoplasmic reticulum chaperone BiP

Yahui Yan,
Claudia Rato,
Lukas Rohland,
Steffen Preissler,
David Ron

Affiliations

Yahui Yan: Cambridge Institute for Medical Research, University of Cambridge
Claudia Rato: Cambridge Institute for Medical Research, University of Cambridge
Lukas Rohland: Cambridge Institute for Medical Research, University of Cambridge
Steffen Preissler: Cambridge Institute for Medical Research, University of Cambridge
David Ron: Cambridge Institute for Medical Research, University of Cambridge

DOI: https://doi.org/10.1038/s41467-019-08450-4
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 15

Abstract

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The role of mesencephalic astrocyte-derived neurotrophic factor (MANF) in maintenance of protein folding homeostasis inside the ER has remained unclear. Here the authors determine the structure of the complex between MANF and the ER-localized chaperone BiP and provide evidence that MANF serves as an anti-nucleotide exchange factor for BiP.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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