Nature Communications (Sep 2016)
Extremotolerant tardigrade genome and improved radiotolerance of human cultured cells by tardigrade-unique protein
- Takuma Hashimoto,
- Daiki D. Horikawa,
- Yuki Saito,
- Hirokazu Kuwahara,
- Hiroko Kozuka-Hata,
- Tadasu Shin-I,
- Yohei Minakuchi,
- Kazuko Ohishi,
- Ayuko Motoyama,
- Tomoyuki Aizu,
- Atsushi Enomoto,
- Koyuki Kondo,
- Sae Tanaka,
- Yuichiro Hara,
- Shigeyuki Koshikawa,
- Hiroshi Sagara,
- Toru Miura,
- Shin-ichi Yokobori,
- Kiyoshi Miyagawa,
- Yutaka Suzuki,
- Takeo Kubo,
- Masaaki Oyama,
- Yuji Kohara,
- Asao Fujiyama,
- Kazuharu Arakawa,
- Toshiaki Katayama,
- Atsushi Toyoda,
- Takekazu Kunieda
Affiliations
- Takuma Hashimoto
- Department of Biological Sciences, Graduate School of Science, The University of Tokyo
- Daiki D. Horikawa
- Department of Biological Sciences, Graduate School of Science, The University of Tokyo
- Yuki Saito
- Department of Biological Sciences, Graduate School of Science, The University of Tokyo
- Hirokazu Kuwahara
- Department of Biological Sciences, Graduate School of Science, The University of Tokyo
- Hiroko Kozuka-Hata
- Medical Proteomics Laboratory, Institute of Medical Science, The University of Tokyo
- Tadasu Shin-I
- Genome Biology Laboratory, National Institute of Genetics
- Yohei Minakuchi
- Comparative Genomics Laboratory, National Institute of Genetics
- Kazuko Ohishi
- Genome Biology Laboratory, National Institute of Genetics
- Ayuko Motoyama
- Comparative Genomics Laboratory, National Institute of Genetics
- Tomoyuki Aizu
- Comparative Genomics Laboratory, National Institute of Genetics
- Atsushi Enomoto
- Laboratory of Molecular Radiology, Graduate School of Medicine, The University of Tokyo
- Koyuki Kondo
- Department of Biological Sciences, Graduate School of Science, The University of Tokyo
- Sae Tanaka
- Department of Biological Sciences, Graduate School of Science, The University of Tokyo
- Yuichiro Hara
- Phyloinformatics Unit, RIKEN Center for Life Science Technologies
- Shigeyuki Koshikawa
- Laboratory of Ecological Genetics, Graduate School of Environmental Science, Hokkaido University
- Hiroshi Sagara
- Medical Proteomics Laboratory, Institute of Medical Science, The University of Tokyo
- Toru Miura
- Laboratory of Ecological Genetics, Graduate School of Environmental Science, Hokkaido University
- Shin-ichi Yokobori
- Department of Applied Life Sciences, Laboratory of Extremophiles, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences
- Kiyoshi Miyagawa
- Laboratory of Molecular Radiology, Graduate School of Medicine, The University of Tokyo
- Yutaka Suzuki
- Department of Computational Biology and Medical Science, Graduate School of Frontier Sciences, The University of Tokyo
- Takeo Kubo
- Department of Biological Sciences, Graduate School of Science, The University of Tokyo
- Masaaki Oyama
- Medical Proteomics Laboratory, Institute of Medical Science, The University of Tokyo
- Yuji Kohara
- Genome Biology Laboratory, National Institute of Genetics
- Asao Fujiyama
- Comparative Genomics Laboratory, National Institute of Genetics
- Kazuharu Arakawa
- Institute for Advanced Biosciences, Keio University
- Toshiaki Katayama
- Database Center for Life Science
- Atsushi Toyoda
- Comparative Genomics Laboratory, National Institute of Genetics
- Takekazu Kunieda
- Department of Biological Sciences, Graduate School of Science, The University of Tokyo
- DOI
- https://doi.org/10.1038/ncomms12808
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 14
Abstract
Tardigrades are resistant to extreme environmental conditions including dehydration, radiation and the vacuum of space. Here the authors present a high-quality genome which displays minimal horizontal gene transfer, and identify the unique tardigrade protein Dsup which suppresses DNA damage.
