Nature Communications (May 2017)
Tau association with synaptic vesicles causes presynaptic dysfunction
- Lujia Zhou,
- Joseph McInnes,
- Keimpe Wierda,
- Matthew Holt,
- Abigail G. Herrmann,
- Rosemary J. Jackson,
- Yu-Chun Wang,
- Jef Swerts,
- Jelle Beyens,
- Katarzyna Miskiewicz,
- Sven Vilain,
- Ilse Dewachter,
- Diederik Moechars,
- Bart De Strooper,
- Tara L. Spires-Jones,
- Joris De Wit,
- Patrik Verstreken
Affiliations
- Lujia Zhou
- VIB-KU Leuven Center for Brain & Disease Research
- Joseph McInnes
- VIB-KU Leuven Center for Brain & Disease Research
- Keimpe Wierda
- VIB-KU Leuven Center for Brain & Disease Research
- Matthew Holt
- VIB-KU Leuven Center for Brain & Disease Research
- Abigail G. Herrmann
- University of Edinburgh, Centre for Cognitive and Neural Systems, Center for Dementia Prevention and Euan MacDonald Centre
- Rosemary J. Jackson
- University of Edinburgh, Centre for Cognitive and Neural Systems, Center for Dementia Prevention and Euan MacDonald Centre
- Yu-Chun Wang
- VIB-KU Leuven Center for Brain & Disease Research
- Jef Swerts
- VIB-KU Leuven Center for Brain & Disease Research
- Jelle Beyens
- VIB-KU Leuven Center for Brain & Disease Research
- Katarzyna Miskiewicz
- VIB-KU Leuven Center for Brain & Disease Research
- Sven Vilain
- VIB-KU Leuven Center for Brain & Disease Research
- Ilse Dewachter
- Catholic University of Louvain, Alzheimer Dementia Group, Institute of Neuroscience
- Diederik Moechars
- A Division of Janssen Pharmaceutica NV, Neuroscience Department, Janssen Research and Development
- Bart De Strooper
- VIB-KU Leuven Center for Brain & Disease Research
- Tara L. Spires-Jones
- University of Edinburgh, Centre for Cognitive and Neural Systems, Center for Dementia Prevention and Euan MacDonald Centre
- Joris De Wit
- VIB-KU Leuven Center for Brain & Disease Research
- Patrik Verstreken
- VIB-KU Leuven Center for Brain & Disease Research
- DOI
- https://doi.org/10.1038/ncomms15295
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 13
Abstract
Mislocalisation of tau occurs in several neurodegenerative diseases and is thought to contribute to synaptic function. The authors show that presynaptically, tau binds to synaptic vesicles via the N-terminus which contributes to synaptic dysfunction.
