Efficacy of different cardiotonic drug on severity of endotoxemia under heart failure coupled with systemic inflammatory syndrome in experiments

Abstract

On the model of systemic inflammatory response syndrome caused by toxi-allergic myocarditis 10-day duration in rabbits the efficacy of 5 days (beginning after 5 days from the injection of staphylococcus toxins) administration of the various pharmacological agents on the endotoxemia intensity has been studied. It has been shown that pathological shifts in cytokine system in myocardium occurs early than in blood. The efficacy of action of the studding cardiotonic drug on the endotoxemia were: Adenocin® > amrinone ≥ digoxin > levosimendan. Influence of Adenocin®, and in less extent digoxin unlike amrinone and levosimendan, leads to the decreasing in the expression of nuclear transcription factor NF-kB and expression of intercellular adhesion molecule-1 (ICAM-1).

Keywords

• сердечная недостаточность
• синдром системного воспалительного ответа
• кардиотонические средства
• эндотоксемия
• внутриклеточная молекула адгезии
• heart failure
• systemic inflammatory response syndrome
• cardiotonic drug
• endotoxemia
• intercellular adhesion molecule-1