Strong histamine torsion Raman spectrum enables direct, rapid, and ultrasensitive detection of allergic diseases

Haogang Zhu; Shuo Liu; Zijing Guo; Kun Yan; Jiancang Shen; Zhiyong Zhang; Jian Chen; Yachong Guo; Lizhe Liu; Xinglong Wu

iScience (Nov 2021)

Strong histamine torsion Raman spectrum enables direct, rapid, and ultrasensitive detection of allergic diseases

Haogang Zhu,
Shuo Liu,
Zijing Guo,
Kun Yan,
Jiancang Shen,
Zhiyong Zhang,
Jian Chen,
Yachong Guo,
Lizhe Liu,
Xinglong Wu

Affiliations

Haogang Zhu: National Laboratory of Solid States Microstructures and Key Laboratory of Modern Acoustics, MOE, Institute of Acoustics, Nanjing University, Nanjing 210093, China
Shuo Liu: National Laboratory of Solid States Microstructures and Key Laboratory of Modern Acoustics, MOE, Institute of Acoustics, Nanjing University, Nanjing 210093, China
Zijing Guo: National Laboratory of Solid States Microstructures and Key Laboratory of Modern Acoustics, MOE, Institute of Acoustics, Nanjing University, Nanjing 210093, China
Kun Yan: National Laboratory of Solid States Microstructures and Key Laboratory of Modern Acoustics, MOE, Institute of Acoustics, Nanjing University, Nanjing 210093, China
Jiancang Shen: National Laboratory of Solid States Microstructures and Key Laboratory of Modern Acoustics, MOE, Institute of Acoustics, Nanjing University, Nanjing 210093, China
Zhiyong Zhang: National Laboratory of Solid States Microstructures and Key Laboratory of Modern Acoustics, MOE, Institute of Acoustics, Nanjing University, Nanjing 210093, China; Corresponding author
Jian Chen: National Laboratory of Solid States Microstructures and Research Institute of Superconductor Electronics, Nanjing University, Nanjing 210093, China
Yachong Guo: National Laboratory of Solid States Microstructures and Key Laboratory of Modern Acoustics, MOE, Institute of Acoustics, Nanjing University, Nanjing 210093, China; Kuang Yaming Honors School, Nanjing University, Nanjing 210023, China; Leibniz-Institut für Polymerforschung Dresden, Hohe Strasse 6, 01069 Dresden, Germany; Corresponding author
Lizhe Liu: National Laboratory of Solid States Microstructures and Key Laboratory of Modern Acoustics, MOE, Institute of Acoustics, Nanjing University, Nanjing 210093, China; Corresponding author
Xinglong Wu: National Laboratory of Solid States Microstructures and Key Laboratory of Modern Acoustics, MOE, Institute of Acoustics, Nanjing University, Nanjing 210093, China; Corresponding author

Journal volume & issue: Vol. 24, no. 11
p. 103384

Abstract

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Summary: Allergic diseases are closely related to degranulation and release of histamine and difficult to diagnose because non-allergic diseases also exhibit the same clinical symptoms as allergy. Here, we report direct, rapid, and ultrasensitive detection of histamine using low-frequency molecular torsion Raman spectroscopy. We show that the low-frequency (3) of histamine reaches 10−8 g/L in water and 10−6 g/L in serum. This scheme thus opens new lines of inquiry regarding the clinical diagnosis of allergic diseases.

Published in iScience

ISSN: 2589-0042 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Science
Website: http://www.cell.com/iscience/home

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