Indian Journal of Ophthalmology (Jan 2014)

Aggressive posterior retinopathy of prematurity in infants ≥1500 g birth weight

  • Gaurav Sanghi,
  • Mangat R Dogra,
  • Deeksha Katoch,
  • Amod Gupta

DOI
https://doi.org/10.4103/0301-4738.128639
Journal volume & issue
Vol. 62, no. 2
pp. 254 – 257

Abstract

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In this retrospective case series, we report the spectrum and outcomes of aggressive posterior retinopathy of prematurity (APROP) in infants ≥1500 g birth weight. Twenty-nine eyes of 15 infants are included. All infants were referred from level I or II nurseries, received supplemental unmonitored oxygen for prolonged duration (>1 week) and had multiple systemic co-morbidities. Of the 29 eyes, 10 (34.5%) had zone 1 and 19 (65.5%) had posterior zone 2 disease. Twenty-five (86.2%) eyes had flat neovascularization and 4 (13.8%) eyes had brush like proliferation. We noticed large vascular loops in 10 (34.5%) eyes. After confluent laser photocoagulation, 22 (75.9%) eyes had a favorable outcome. The study concludes that APROP in heavier (≥1500 g birth weight) premature infants occurs mostly in posterior zone 2 with flat neovascularization and atypical features like large vascular loops. Supplemental unmonitored oxygen for prolonged duration and multiple systemic co-morbidities could be a contributing factor.

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