What the BTBR/J mouse has taught us about diabetes and diabetic complications

Mark P. Keller; Kelly L. Hudkins; Anath Shalev; Sushant Bhatnagar; Melkam A. Kebede; Matthew J. Merrins; Dawn Belt Davis; Charles E. Alpers; Michelle E. Kimple; Alan D. Attie

iScience (Jul 2023)

What the BTBR/J mouse has taught us about diabetes and diabetic complications

Mark P. Keller,
Kelly L. Hudkins,
Anath Shalev,
Sushant Bhatnagar,
Melkam A. Kebede,
Matthew J. Merrins,
Dawn Belt Davis,
Charles E. Alpers,
Michelle E. Kimple,
Alan D. Attie

Affiliations

Mark P. Keller: Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA
Kelly L. Hudkins: Department of Pathology, University of Washington Medical Center, Seattle, WA 98195, USA
Anath Shalev: Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Alabama at Birmingham, Birmingham, AL 35294, UK
Sushant Bhatnagar: Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Alabama at Birmingham, Birmingham, AL 35294, UK
Melkam A. Kebede: School of Medical Sciences, Faculty of Medicine and Health, Charles Perkins Centre, University of Sydney, Camperdown, Sydney, NSW 2006, Australia
Matthew J. Merrins: Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA; William S. Middleton Memorial Veterans Hospital, Madison, WI 53705, USA
Dawn Belt Davis: Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA; William S. Middleton Memorial Veterans Hospital, Madison, WI 53705, USA
Charles E. Alpers: Department of Pathology, University of Washington Medical Center, Seattle, WA 98195, USA
Michelle E. Kimple: Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA; William S. Middleton Memorial Veterans Hospital, Madison, WI 53705, USA
Alan D. Attie: Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA; Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA; Department of Chemistry, University of Wisconsin-Madison, Madison, WI 53706, USA; Corresponding author

Journal volume & issue: Vol. 26, no. 7
p. 107036

Abstract

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Summary: Human and mouse genetics have delivered numerous diabetogenic loci, but it is mainly through the use of animal models that the pathophysiological basis for their contribution to diabetes has been investigated. More than 20 years ago, we serendipidously identified a mouse strain that could serve as a model of obesity-prone type 2 diabetes, the BTBR (Black and Tan Brachyury) mouse (BTBR T+ Itpr3tf/J, 2018) carrying the Lepob mutation. We went on to discover that the BTBR-Lepob mouse is an excellent model of diabetic nephropathy and is now widely used by nephrologists in academia and the pharmaceutical industry. In this review, we describe the motivation for developing this animal model, the many genes identified and the insights about diabetes and diabetes complications derived from >100 studies conducted in this remarkable animal model.

Published in iScience

ISSN: 2589-0042 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Science
Website: http://www.cell.com/iscience/home

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