Nature Communications (Apr 2018)
Macrophage-derived IL-1β/NF-κB signaling mediates parenteral nutrition-associated cholestasis
- Karim C. El Kasmi,
- Padade M. Vue,
- Aimee L. Anderson,
- Michael W. Devereaux,
- Swati Ghosh,
- Natarajan Balasubramaniyan,
- Sophie A. Fillon,
- Carola Dahrenmoeller,
- Ayed Allawzi,
- Crystal Woods,
- Sarah McKenna,
- Clyde J. Wright,
- Linda Johnson,
- Angelo D’Alessandro,
- Julie A. Reisz,
- Eva Nozik-Grayck,
- Frederick J. Suchy,
- Ronald J. Sokol
Affiliations
- Karim C. El Kasmi
- Department of Pediatrics, Section of Pediatric Gastroenterology, Hepatology and Nutrition, University of Colorado School of Medicine
- Padade M. Vue
- Department of Pediatrics, Section of Pediatric Gastroenterology, Hepatology and Nutrition, University of Colorado School of Medicine
- Aimee L. Anderson
- Department of Pediatrics, Section of Pediatric Gastroenterology, Hepatology and Nutrition, University of Colorado School of Medicine
- Michael W. Devereaux
- Department of Pediatrics, Section of Pediatric Gastroenterology, Hepatology and Nutrition, University of Colorado School of Medicine
- Swati Ghosh
- Department of Pediatrics, Section of Pediatric Gastroenterology, Hepatology and Nutrition, University of Colorado School of Medicine
- Natarajan Balasubramaniyan
- Department of Pediatrics, Section of Pediatric Gastroenterology, Hepatology and Nutrition, University of Colorado School of Medicine
- Sophie A. Fillon
- Department of Pediatrics, Section of Pediatric Gastroenterology, Hepatology and Nutrition, University of Colorado School of Medicine
- Carola Dahrenmoeller
- Department of Pediatrics, Section of Pediatric Gastroenterology, Hepatology and Nutrition, University of Colorado School of Medicine
- Ayed Allawzi
- Cardiovascular Pulmonary Research and Division of Pediatric Critical Care, Department of Pediatrics, University of Colorado School of Medicine
- Crystal Woods
- Department of Pediatrics, Section of Pediatric Gastroenterology, Hepatology and Nutrition, University of Colorado School of Medicine
- Sarah McKenna
- Section of Neonatology, Department of Pediatrics, University of Colorado School of Medicine
- Clyde J. Wright
- Section of Neonatology, Department of Pediatrics, University of Colorado School of Medicine
- Linda Johnson
- Department of Pathology, University of Colorado School of Medicine
- Angelo D’Alessandro
- Cardiovascular Pulmonary Research and Division of Pediatric Critical Care, Department of Pediatrics, University of Colorado School of Medicine
- Julie A. Reisz
- Cardiovascular Pulmonary Research and Division of Pediatric Critical Care, Department of Pediatrics, University of Colorado School of Medicine
- Eva Nozik-Grayck
- Cardiovascular Pulmonary Research and Division of Pediatric Critical Care, Department of Pediatrics, University of Colorado School of Medicine
- Frederick J. Suchy
- Department of Pediatrics, Section of Pediatric Gastroenterology, Hepatology and Nutrition, University of Colorado School of Medicine
- Ronald J. Sokol
- Department of Pediatrics, Section of Pediatric Gastroenterology, Hepatology and Nutrition, University of Colorado School of Medicine
- DOI
- https://doi.org/10.1038/s41467-018-03764-1
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 14
Abstract
The authors previously developed a mouse model of parenteral nutrition-associated cholestasis (PNAC) that is dependent on parenteral phytosterols and intestinal injury with DSS. Here they refine the model and show that PNAC pathology is dependent on recruitment of hepatic macrophages and IL-1 signaling.
