DNA sequence-dependent activity and base flipping mechanisms of DNMT1 regulate genome-wide DNA methylation

Sabrina Adam; Hiwot Anteneh; Maximilian Hornisch; Vincent Wagner; Jiuwei Lu; Nicole E. Radde; Pavel Bashtrykov; Jikui Song; Albert Jeltsch

doi:10.1038/s41467-020-17531-8

Nature Communications (Jul 2020)

DNA sequence-dependent activity and base flipping mechanisms of DNMT1 regulate genome-wide DNA methylation

Sabrina Adam,
Hiwot Anteneh,
Maximilian Hornisch,
Vincent Wagner,
Jiuwei Lu,
Nicole E. Radde,
Pavel Bashtrykov,
Jikui Song,
Albert Jeltsch

Affiliations

Sabrina Adam: Department of Biochemistry, Institute of Biochemistry and Technical Biochemistry, University of Stuttgart
Hiwot Anteneh: Department of Biochemistry, University of California
Maximilian Hornisch: Department of Biochemistry, Institute of Biochemistry and Technical Biochemistry, University of Stuttgart
Vincent Wagner: Institute for Systems Theory and Automatic Control, University of Stuttgart
Jiuwei Lu: Department of Biochemistry, University of California
Nicole E. Radde: Institute for Systems Theory and Automatic Control, University of Stuttgart
Pavel Bashtrykov: Department of Biochemistry, Institute of Biochemistry and Technical Biochemistry, University of Stuttgart
Jikui Song: Department of Biochemistry, University of California
Albert Jeltsch: Department of Biochemistry, Institute of Biochemistry and Technical Biochemistry, University of Stuttgart

DOI: https://doi.org/10.1038/s41467-020-17531-8
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 15

Abstract

Read online

DNA methylation is one of the major epigenetic mechanisms that critically influence gene expression, genomic stability and cell differentiation. Here, the authors study DNMT1 in complex with DNA substrates and systematically analyze the mechanism and specificity of DNMT1.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal