Structural and dynamic insights into supra-physiological activation and allosteric modulation of a muscarinic acetylcholine receptor

Jun Xu; Qinggong Wang; Harald Hübner; Yunfei Hu; Xiaogang Niu; Haoqing Wang; Shoji Maeda; Asuka Inoue; Yuyong Tao; Peter Gmeiner; Yang Du; Changwen Jin; Brian K. Kobilka

doi:10.1038/s41467-022-35726-z

Nature Communications (Jan 2023)

Structural and dynamic insights into supra-physiological activation and allosteric modulation of a muscarinic acetylcholine receptor

Jun Xu,
Qinggong Wang,
Harald Hübner,
Yunfei Hu,
Xiaogang Niu,
Haoqing Wang,
Shoji Maeda,
Asuka Inoue,
Yuyong Tao,
Peter Gmeiner,
Yang Du,
Changwen Jin,
Brian K. Kobilka

Affiliations

Jun Xu: Department of Molecular and Cellular Physiology, Stanford University School of Medicine
Qinggong Wang: Kobilka Institute of Innovative Drug Discovery, School of Life and Health Sciences, Chinese University of Hong Kong
Harald Hübner: Department of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich-Alexander University
Yunfei Hu: Beijing Nuclear Magnetic Resonance Center, College of Chemistry and Molecular Engineering, Peking University
Xiaogang Niu: Beijing Nuclear Magnetic Resonance Center, College of Chemistry and Molecular Engineering, Peking University
Haoqing Wang: Department of Molecular and Cellular Physiology, Stanford University School of Medicine
Shoji Maeda: Department of Molecular and Cellular Physiology, Stanford University School of Medicine
Asuka Inoue: Graduate School of Pharmaceutical Sciences, Tohoku University
Yuyong Tao: Division of Life Sciences and Medicine, University of Science and Technology of China
Peter Gmeiner: Department of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich-Alexander University
Yang Du: Kobilka Institute of Innovative Drug Discovery, School of Life and Health Sciences, Chinese University of Hong Kong
Changwen Jin: Beijing Nuclear Magnetic Resonance Center, College of Chemistry and Molecular Engineering, Peking University
Brian K. Kobilka: Department of Molecular and Cellular Physiology, Stanford University School of Medicine

DOI: https://doi.org/10.1038/s41467-022-35726-z
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 16

Abstract

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Here, using cryo-electron microscopy and solution NMR, the authors reveal the structural and dynamic mechanisms underlying the signaling versatility of a muscarinic receptor regulated by orthosteric and allosteric ligands.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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