Nature Communications (Oct 2022)

ZIP1+ fibroblasts protect lung cancer against chemotherapy via connexin-43 mediated intercellular Zn2+ transfer

  • Chen Ni,
  • Xiaohan Lou,
  • Xiaohan Yao,
  • Linlin Wang,
  • Jiajia Wan,
  • Xixi Duan,
  • Jialu Liang,
  • Kaili Zhang,
  • Yuanyuan Yang,
  • Li Zhang,
  • Chanjun Sun,
  • Zhenzhen Li,
  • Ming Wang,
  • Linyu Zhu,
  • Dekang Lv,
  • Zhihai Qin

DOI
https://doi.org/10.1038/s41467-022-33521-4
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 20

Abstract

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Cancer-associated fibroblasts (CAFs) have been implicated in lung cancer chemo-resistance. Here the authors show that a zinc-transporter positive CAF subset is enriched in lung cancer models after chemotherapy and actively transfers zinc to cancer cells, promoting ABCB1-mediated chemo-resistance.