Nature Communications (Sep 2022)
Molecular insights into antibody-mediated protection against the prototypic simian immunodeficiency virus
- Fangzhu Zhao,
- Zachary T. Berndsen,
- Nuria Pedreño-Lopez,
- Alison Burns,
- Joel D. Allen,
- Shawn Barman,
- Wen-Hsin Lee,
- Srirupa Chakraborty,
- Sandrasegaram Gnanakaran,
- Leigh M. Sewall,
- Gabriel Ozorowski,
- Oliver Limbo,
- Ge Song,
- Peter Yong,
- Sean Callaghan,
- Jessica Coppola,
- Kim L. Weisgrau,
- Jeffrey D. Lifson,
- Rebecca Nedellec,
- Thomas B. Voigt,
- Fernanda Laurino,
- Johan Louw,
- Brandon C. Rosen,
- Michael Ricciardi,
- Max Crispin,
- Ronald C. Desrosiers,
- Eva G. Rakasz,
- David I. Watkins,
- Raiees Andrabi,
- Andrew B. Ward,
- Dennis R. Burton,
- Devin Sok
Affiliations
- Fangzhu Zhao
- Department of Immunology and Microbiology, The Scripps Research Institute
- Zachary T. Berndsen
- IAVI Neutralizing Antibody Center, The Scripps Research Institute
- Nuria Pedreño-Lopez
- Department of Pathology, George Washington University
- Alison Burns
- Department of Immunology and Microbiology, The Scripps Research Institute
- Joel D. Allen
- School of Biological Sciences, University of Southampton
- Shawn Barman
- Department of Immunology and Microbiology, The Scripps Research Institute
- Wen-Hsin Lee
- IAVI Neutralizing Antibody Center, The Scripps Research Institute
- Srirupa Chakraborty
- Theoretical Biology and Biophysics Group, Los Alamos National Laboratory
- Sandrasegaram Gnanakaran
- Theoretical Biology and Biophysics Group, Los Alamos National Laboratory
- Leigh M. Sewall
- IAVI Neutralizing Antibody Center, The Scripps Research Institute
- Gabriel Ozorowski
- IAVI Neutralizing Antibody Center, The Scripps Research Institute
- Oliver Limbo
- IAVI Neutralizing Antibody Center, The Scripps Research Institute
- Ge Song
- Department of Immunology and Microbiology, The Scripps Research Institute
- Peter Yong
- Department of Immunology and Microbiology, The Scripps Research Institute
- Sean Callaghan
- Department of Immunology and Microbiology, The Scripps Research Institute
- Jessica Coppola
- Department of Immunology and Microbiology, The Scripps Research Institute
- Kim L. Weisgrau
- Wisconsin National Primate Research Center, University of Wisconsin-Madison
- Jeffrey D. Lifson
- AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research
- Rebecca Nedellec
- Department of Immunology and Microbiology, The Scripps Research Institute
- Thomas B. Voigt
- Department of Pathology, George Washington University
- Fernanda Laurino
- Department of Pathology, George Washington University
- Johan Louw
- Department of Pathology, George Washington University
- Brandon C. Rosen
- Department of Pathology, George Washington University
- Michael Ricciardi
- Department of Pathology, George Washington University
- Max Crispin
- School of Biological Sciences, University of Southampton
- Ronald C. Desrosiers
- Department of Pathology, Miller School of Medicine, University of Miami
- Eva G. Rakasz
- Wisconsin National Primate Research Center, University of Wisconsin-Madison
- David I. Watkins
- Department of Pathology, George Washington University
- Raiees Andrabi
- Department of Immunology and Microbiology, The Scripps Research Institute
- Andrew B. Ward
- IAVI Neutralizing Antibody Center, The Scripps Research Institute
- Dennis R. Burton
- Department of Immunology and Microbiology, The Scripps Research Institute
- Devin Sok
- Department of Immunology and Microbiology, The Scripps Research Institute
- DOI
- https://doi.org/10.1038/s41467-022-32783-2
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 16
Abstract
SIVmac239 infection of macaques is a favored model of human HIV infection, but antibody-mediated protection for SIVmac239 is insufficiently understood. Here, Zhao and Berndsen et al isolated nAbs and confirmed protection against SIVmac239 infection in passive transfer studies in macaques. The nAb was used to provide the first high-resolution structure of a rhesus SIV trimer by CryoEM. Analysis of the glycosylation pattern of this SIV trimer suggests a denser glycan shield on Env for rhesus SIV compared to chimpanzee SIV or HIV-1, which partially explains the poor nAb response of rhesus macaques to SIVmac239 infection.
