Inside the biology of early T-cell precursor acute lymphoblastic leukemia: the perfect trick

Francesco Tarantini; Cosimo Cumbo; Luisa Anelli; Antonella Zagaria; Giorgina Specchia; Pellegrino Musto; Francesco Albano

doi:10.1186/s40364-021-00347-z

Biomarker Research (Dec 2021)

Inside the biology of early T-cell precursor acute lymphoblastic leukemia: the perfect trick

Francesco Tarantini,
Cosimo Cumbo,
Luisa Anelli,
Antonella Zagaria,
Giorgina Specchia,
Pellegrino Musto,
Francesco Albano

Affiliations

Francesco Tarantini: Department of Emergency and Organ Transplantation (D.E.T.O.) - Hematology and Stem Cell Transplantation Unit, University of Bari “Aldo Moro”
Cosimo Cumbo: Department of Emergency and Organ Transplantation (D.E.T.O.) - Hematology and Stem Cell Transplantation Unit, University of Bari “Aldo Moro”
Luisa Anelli: Department of Emergency and Organ Transplantation (D.E.T.O.) - Hematology and Stem Cell Transplantation Unit, University of Bari “Aldo Moro”
Antonella Zagaria: Department of Emergency and Organ Transplantation (D.E.T.O.) - Hematology and Stem Cell Transplantation Unit, University of Bari “Aldo Moro”
Giorgina Specchia: School of Medicine, University of Bari “Aldo Moro”
Pellegrino Musto: Department of Emergency and Organ Transplantation (D.E.T.O.) - Hematology and Stem Cell Transplantation Unit, University of Bari “Aldo Moro”
Francesco Albano: Department of Emergency and Organ Transplantation (D.E.T.O.) - Hematology and Stem Cell Transplantation Unit, University of Bari “Aldo Moro”

DOI: https://doi.org/10.1186/s40364-021-00347-z
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 8

Abstract

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Abstract Early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) is a rare, distinct subtype of T-ALL characterized by genomic instability, a dismal prognosis and refractoriness to standard chemotherapy. Since its first description in 2009, the expanding knowledge of its intricate biology has led to the definition of a stem cell leukemia with a combined lymphoid-myeloid potential: the perfect trick. Several studies in the last decade aimed to better characterize this new disease, but it was recognized as a distinct entity only in 2016. We review current insights into the biology of ETP-ALL and discuss the pathogenesis, genomic features and their impact on the clinical course in the precision medicine era today.

Published in Biomarker Research

ISSN: 2050-7771 (Online)
Publisher: BMC
Country of publisher: United Kingdom
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: https://biomarkerres.biomedcentral.com/

About the journal

Abstract

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