MORPHOMETRIC CHARACTERISTICS OF NEPHRITIC SINUS AND PARECHYME DURING THE AGEING PROCESS IN HUMAN

Abstract

The ageing of organism is a continues proces manifested by changing in every tissue and organ. The progressing of ageing is associased with many changes in macroscopic look, structure and function of kidney.Considering the literature data on the importance of healthy kidney in function of organism, we want to bind the ageing process in a healthy kidney with changes in nephritic sinus and parenchyme brought by ageing.The investigation is done on 50 fresh sampels of postmortal adult human kidneys without and kidney disease found. On the frontal section the dimensions of sinus were defined (longitude and width) as well as dimensions of parenchyme (width of cortex and medula) on the left and right kidney. We devided tissue sampels in six ageing categories: I (20-29); II (30-39); III (40-49); IV (50-59); V (60-69) and VI (more then 70 years).The dimensions of left and right nephritic sinus show tendency of continuing increase from I to VI ageing group with statistically significant difference in sinus width (p<0,05), between I and VI ageing group while the difference in longitude was (p<0,01) between I and IV and (p<0,05) between I and V and VI. The width of cortex and medulls of kidney parenchyme doesn’t show any statistically significant difference in V to I and in VI to V ageing group (p<0,01).It is evident that dimensions of nephritic sinus increase during thickning of kidney parenchyme which causes reduction of whole kidney.

Keywords

• nephritic sinus
• parenchyme of kidney
• ageing