Pan-cancer transcriptomic analysis associates long non-coding RNAs with key mutational driver events

Arghavan Ashouri; Volkan I. Sayin; Jimmy Van den Eynden; Simranjit X. Singh; Thales Papagiannakopoulos; Erik Larsson

doi:10.1038/ncomms13197

Nature Communications (Oct 2016)

Pan-cancer transcriptomic analysis associates long non-coding RNAs with key mutational driver events

Arghavan Ashouri,
Volkan I. Sayin,
Jimmy Van den Eynden,
Simranjit X. Singh,
Thales Papagiannakopoulos,
Erik Larsson

Affiliations

Arghavan Ashouri: Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, The Sahlgrenska Academy, University of Gothenburg
Volkan I. Sayin: Department of Pathology and Perlmutter Cancer Center, New York University School of Medicine
Jimmy Van den Eynden: Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, The Sahlgrenska Academy, University of Gothenburg
Simranjit X. Singh: Department of Pathology and Perlmutter Cancer Center, New York University School of Medicine
Thales Papagiannakopoulos: Department of Pathology and Perlmutter Cancer Center, New York University School of Medicine
Erik Larsson: Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, The Sahlgrenska Academy, University of Gothenburg

DOI: https://doi.org/10.1038/ncomms13197
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 13

Abstract

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Long non-coding RNAs are implicated in multiple aspects of tumourigenesis. Here, the authors generate a landscape of these macromolecules in a wide array of cancer types and examine which RNAs are transcriptionally altered in relation to somatic driver mutations in established coding cancer genes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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