International Journal of Nanomedicine (Feb 2019)
Magnetic multiwalled carbon nanotubes with controlled release of epirubicin: an intravesical instillation system for bladder cancer
Abstract
Ning Suo,1 Muwen Wang,1 Yang Jin,1 Jun Ding,2 Xueping Gao,3 Xiaoliang Sun,1 Haiyang Zhang,1 Meng Cui,4 Jilu Zheng,1 Nianlu Li,5 Xunbo Jin,1,* Shaobo Jiang1,* 1Department of Urology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, China; 2Department of Mechanical Engineering, University of Maryland, Baltimore County, Baltimore, MD, 21250, USA; 3School of Material Science and Engineering, Shandong University, Jinan 250100, China; 4Department of Urology, Shandong Provincial Maternity and Childcare Hospital, Jinan 250014, China; 5School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China *These authors contributed equally to this work Background: Traditional intravesical instillation treatment in bladder cancer has limited efficacy, which results in a high frequency of recurrence.Purpose: The aim of this study was to report on an epirubicin (EPI)-loaded magnetic multiwalled carbon nanotube (mMWCNTs-EPI) system for intravesical instillation in place of the current formulation.Methods: The mMWCNTs-EPI system was formulated with carboxylated MWCNTs, Fe3O4 magnetic nanoparticles, and EPI. Features and antitumor activity of the system were investigated.Results: Under the effect of external magnets, the mMWCNTs-EPI system showed sustained release and prolonged retention behavior and better antitumor activity than free EPI. The mMWCNTs-EPI system had higher efficiency in enhancing cytotoxicity and inhibiting proliferation in vitro and in vivo than free EPI. Our studies also revealed the atoxic nature of mMWCNTs.Conclusion: These findings suggested that mMWCNTs are effective intravesical instillation agents with great potential for clinical application. Keywords: carbon nanotubes, intravesical instillation, epirubicin, intravesical drug delivery
