KDM6B promotes activation of the oncogenic CDK4/6-pRB-E2F pathway by maintaining enhancer activity in MYCN-amplified neuroblastoma

Alexandra D’Oto; Jie Fang; Hongjian Jin; Beisi Xu; Shivendra Singh; Anoushka Mullasseril; Victoria Jones; Ahmed Abu-Zaid; Xinyu von Buttlar; Bailey Cooke; Dongli Hu; Jason Shohet; Andrew J. Murphy; Andrew M. Davidoff; Jun Yang

doi:10.1038/s41467-021-27502-2

Nature Communications (Dec 2021)

KDM6B promotes activation of the oncogenic CDK4/6-pRB-E2F pathway by maintaining enhancer activity in MYCN-amplified neuroblastoma

Alexandra D’Oto,
Jie Fang,
Hongjian Jin,
Beisi Xu,
Shivendra Singh,
Anoushka Mullasseril,
Victoria Jones,
Ahmed Abu-Zaid,
Xinyu von Buttlar,
Bailey Cooke,
Dongli Hu,
Jason Shohet,
Andrew J. Murphy,
Andrew M. Davidoff,
Jun Yang

Affiliations

Alexandra D’Oto: Department of Surgery, St. Jude Children’s Research Hospital
Jie Fang: Department of Surgery, St. Jude Children’s Research Hospital
Hongjian Jin: Center for Applied Bioinformatics, St. Jude Children’s Research Hospital
Beisi Xu: Center for Applied Bioinformatics, St. Jude Children’s Research Hospital
Shivendra Singh: Department of Surgery, St. Jude Children’s Research Hospital
Anoushka Mullasseril: Department of Surgery, St. Jude Children’s Research Hospital
Victoria Jones: Department of Surgery, St. Jude Children’s Research Hospital
Ahmed Abu-Zaid: Department of Surgery, St. Jude Children’s Research Hospital
Xinyu von Buttlar: Department of Surgery, St. Jude Children’s Research Hospital
Bailey Cooke: Department of Surgery, St. Jude Children’s Research Hospital
Dongli Hu: Department of Surgery, St. Jude Children’s Research Hospital
Jason Shohet: Department of Pediatrics, University of Massachusetts Medical School
Andrew J. Murphy: Department of Surgery, St. Jude Children’s Research Hospital
Andrew M. Davidoff: Department of Surgery, St. Jude Children’s Research Hospital
Jun Yang: Department of Surgery, St. Jude Children’s Research Hospital

DOI: https://doi.org/10.1038/s41467-021-27502-2
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 19

Abstract

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The histone demethylase KDM6B is reported to be essential for neuroblastoma cell survival. Here the authors show that KDM6B regulates CDK4/6-pRB-E2F pathway through H3K27me3-dependent enhancer-promoter interactions in neuroblastoma.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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