Multidisciplinary Approaches Identify Compounds that Bind to Human ACE2 or SARS-CoV-2 Spike Protein as Candidates to Block SARS-CoV-2–ACE2 Receptor Interactions

Christopher J. Day; Benjamin Bailly; Patrice Guillon; Larissa Dirr; Freda E.-C. Jen; Belinda L. Spillings; Johnson Mak; Mark von Itzstein; Thomas Haselhorst; Michael P. Jennings

doi:10.1128/mBio.03681-20

mBio (Apr 2021)

Multidisciplinary Approaches Identify Compounds that Bind to Human ACE2 or SARS-CoV-2 Spike Protein as Candidates to Block SARS-CoV-2–ACE2 Receptor Interactions

Christopher J. Day,
Benjamin Bailly,
Patrice Guillon,
Larissa Dirr,
Freda E.-C. Jen,
Belinda L. Spillings,
Johnson Mak,
Mark von Itzstein,
Thomas Haselhorst,
Michael P. Jennings

Affiliations

Christopher J. Day: Institute for Glycomics, Griffith University, Gold Coast Campus, Gold Coast, QLD, Australia
Benjamin Bailly: ORCiD; Institute for Glycomics, Griffith University, Gold Coast Campus, Gold Coast, QLD, Australia
Patrice Guillon: Institute for Glycomics, Griffith University, Gold Coast Campus, Gold Coast, QLD, Australia
Larissa Dirr: Institute for Glycomics, Griffith University, Gold Coast Campus, Gold Coast, QLD, Australia
Freda E.-C. Jen: Institute for Glycomics, Griffith University, Gold Coast Campus, Gold Coast, QLD, Australia
Belinda L. Spillings: Institute for Glycomics, Griffith University, Gold Coast Campus, Gold Coast, QLD, Australia
Johnson Mak: Institute for Glycomics, Griffith University, Gold Coast Campus, Gold Coast, QLD, Australia
Mark von Itzstein: Institute for Glycomics, Griffith University, Gold Coast Campus, Gold Coast, QLD, Australia
Thomas Haselhorst: Institute for Glycomics, Griffith University, Gold Coast Campus, Gold Coast, QLD, Australia
Michael P. Jennings: ORCiD; Institute for Glycomics, Griffith University, Gold Coast Campus, Gold Coast, QLD, Australia

DOI: https://doi.org/10.1128/mBio.03681-20
Journal volume & issue: Vol. 12, no. 2

Abstract

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SARS-CoV-2, the causative agent of COVID-19, has caused more than 60 million cases worldwide with almost 1.5 million deaths as of November 2020. Repurposing existing drugs is the most rapid path to clinical intervention for emerging diseases.

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

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