Cooperation between PRMT1 and PRMT6 drives lung cancer health disparities among Black/African American men

Pei-Ying Wu; Michelle Van Scoyk; Stephanie S. McHale; Chu-Fang Chou; Gregory Riddick; Kamran Farouq; Bin Hu; Vita Kraskauskiene; Jennifer Koblinski; Charles Lyons; Arjun Rijal; Vignesh Vudatha; Dongyu Zhang; Jose G. Trevino; Rachit D. Shah; Patrick Nana-Sinkam; Yong Huang; Shwu-Fan Ma; Imre Noth; Chanita Hughes-Halbert; Victoria L. Seewaldt; Ching-Yi Chen; Robert A. Winn

iScience (Feb 2024)

Cooperation between PRMT1 and PRMT6 drives lung cancer health disparities among Black/African American men

Pei-Ying Wu,
Michelle Van Scoyk,
Stephanie S. McHale,
Chu-Fang Chou,
Gregory Riddick,
Kamran Farouq,
Bin Hu,
Vita Kraskauskiene,
Jennifer Koblinski,
Charles Lyons,
Arjun Rijal,
Vignesh Vudatha,
Dongyu Zhang,
Jose G. Trevino,
Rachit D. Shah,
Patrick Nana-Sinkam,
Yong Huang,
Shwu-Fan Ma,
Imre Noth,
Chanita Hughes-Halbert,
Victoria L. Seewaldt,
Ching-Yi Chen,
Robert A. Winn

Affiliations

Pei-Ying Wu: Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA
Michelle Van Scoyk: Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA
Stephanie S. McHale: Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA
Chu-Fang Chou: Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA
Gregory Riddick: Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA
Kamran Farouq: Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA
Bin Hu: Department of Pathology and Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA
Vita Kraskauskiene: Department of Pathology and Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA
Jennifer Koblinski: Department of Pathology and Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA
Charles Lyons: Department of Pathology and Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA
Arjun Rijal: Department of Pathology and Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA
Vignesh Vudatha: Division of Surgical Oncology and Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA
Dongyu Zhang: Division of Surgical Oncology and Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA
Jose G. Trevino: Division of Surgical Oncology and Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA
Rachit D. Shah: Division of Cardiothoracic Surgery, Virginia Commonwealth University, Richmond, VA, USA
Patrick Nana-Sinkam: Division of Pulmonary Disease and Critical Care Medicine, Virginia Commonwealth University, Richmond, VA, USA
Yong Huang: Division of Pulmonary and Critical Care, University of Virginia, Charlottesville, VA, USA
Shwu-Fan Ma: Division of Pulmonary and Critical Care, University of Virginia, Charlottesville, VA, USA
Imre Noth: Division of Pulmonary and Critical Care, University of Virginia, Charlottesville, VA, USA
Chanita Hughes-Halbert: Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA
Victoria L. Seewaldt: City of Hope Comprehensive Cancer Center, Duarte, CA, USA
Ching-Yi Chen: Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA
Robert A. Winn: Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA; Corresponding author

Journal volume & issue: Vol. 27, no. 2
p. 108858

Abstract

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Summary: Lung cancer is the third most common cancer with Black/AA men showing higher risk and poorer outcomes than NHW men. Lung cancer disparities are multifactorial, driven by tobacco exposure, inequities in care access, upstream health determinants, and molecular determinants including biological and genetic factors. Elevated expressions of protein arginine methyltransferases (PRMTs) correlating with poorer prognosis have been observed in many cancers. Most importantly, our study shows that PRMT6 displays higher expression in lung cancer tissues of Black/AA men compared to NHW men. In this study, we investigated the underlying mechanism of PRMT6 and its cooperation with PRMT1 to form a heteromer as a driver of lung cancer. Disrupting PRMT1/PRMT6 heteromer by a competitive peptide reduced proliferation in non-small cell lung cancer cell lines and patient-derived organoids, therefore, giving rise to a more strategic approach in the treatment of Black/AA men with lung cancer and to eliminate cancer health disparities.

Published in iScience

ISSN: 2589-0042 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Science
Website: http://www.cell.com/iscience/home

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