C1q acts in the tumour microenvironment as a cancer-promoting factor independently of complement activation

Roberta Bulla; Claudio Tripodo; Damiano Rami; Guang Sheng Ling; Chiara Agostinis; Carla Guarnotta; Sonia Zorzet; Paolo Durigutto; Marina Botto; Francesco Tedesco

doi:10.1038/ncomms10346

Nature Communications (Feb 2016)

C1q acts in the tumour microenvironment as a cancer-promoting factor independently of complement activation

Roberta Bulla,
Claudio Tripodo,
Damiano Rami,
Guang Sheng Ling,
Chiara Agostinis,
Carla Guarnotta,
Sonia Zorzet,
Paolo Durigutto,
Marina Botto,
Francesco Tedesco

Affiliations

Roberta Bulla: Department of Life Sciences, University of Trieste
Claudio Tripodo: Department of Human Pathology, University of Palermo
Damiano Rami: Department of Life Sciences, University of Trieste
Guang Sheng Ling: Department of Medicine, Centre for Complement and Inflammation Research, Imperial College
Chiara Agostinis: Institute for Maternal and Child Health, Istituto di Ricovero e Cura a Carattere Scientifico Burlo Garofolo
Carla Guarnotta: Department of Human Pathology, University of Palermo
Sonia Zorzet: Department of Life Sciences, University of Trieste
Paolo Durigutto: Department of Life Sciences, University of Trieste
Marina Botto: Department of Medicine, Centre for Complement and Inflammation Research, Imperial College
Francesco Tedesco: Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Auxologico Italiano

DOI: https://doi.org/10.1038/ncomms10346
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 11

Abstract

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C1q is known to initiate the activation of the complement classical pathway. Here, the authors show the C1q is expressed in the tumour microenvironment and can promote cancer cell migration and adhesion in a complement activation-independent manner.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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