Veterinary Medicine: Research and Reports (Jun 2023)
Cytokine Adsorption as an Adjunctive Treatment for Patients with Immune-Mediated Hemolytic Anemia Receiving Therapeutic Plasma Exchange: A Case Series of 3 Dogs
Abstract
John Meagher, Jeanette Hendricks, Adam Eatroff Advanced Critical Care Emergency and Specialty Services, Culver City, CA, USACorrespondence: John Meagher, Advanced Critical Care Emergency and Specialty Services, 9599 Jefferson Blvd, Culver City, CA, 90232, USA, Tel + 1 310 558 6100, Fax + 1 310 558 6199, Email [email protected]: The use of cytokine adsorption is an emerging treatment for inflammatory diseases in human medicine. There are few reports of this treatment modality in veterinary medicine and no reports of the use of a cytokine adsorbent for immune-mediated hemolytic anemia (IMHA). These case reports illustrate the use of a cytokine adsorbent as an adjunctive treatment during therapeutic plasma exchange (TPE). All dogs were unresponsive to conventional treatment or were severely affected by rapid hemolysis of red blood cells. The aim was to treat all dogs with three sequential TPE sessions; however, one dog died before completion of three sessions and one dog required additional sessions. Preliminary evidence indicates that the use of a cytokine adsorption is well tolerated and can be considered as an adjunct in the management of IMHA that is severe or refractory to traditional treatment.Keywords: IMHA, TPE, IL-6, VetResQ, CytoSorb
