Simplifying cancer: binary pan-cancer superclasses stratified by opposite YAP/TEAD effects

Abstract

The inherent complexity of cancer complicates treatment. Identifying higher-order principles that govern cancer biology can circumvent this problem and pinpoint broadly applicable treatment options. We recently found that opposite expression and pro- versus anti-cancer activity of a single transcriptional complex functionally stratifies cancer into binary superclasses.

Keywords

• yap
• taz/wwtr1
• neuroendocrine cancer
• small cell lung cancer
• leukemia