Infection and Drug Resistance (Aug 2021)
Differentiating Between an Atypical Hepatic Abscess and Tumor Metastasis Using Magnetic Resonance Imaging and Hepatobiliary Phase Imaging
Abstract
Li-Yong Zhuo,* Li-Hong Xing,* Xi Ma, Yu Zhang, Ze-Peng Ma, Xiao-Ping Yin, Jia-Ning Wang Department of CT-MRI Diagnostic, Affiliated Hospital of Hebei University, Baoding, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiao-Ping Yin; Jia-Ning WangDepartment of CT-MRI Diagnostic, Affiliated Hospital of Hebei University, 212 Eastern Yuhua Road, Baoding City, Hebei Province, 071000, People’s Republic of ChinaTel +8613103128133; +8618233289724Email [email protected]; [email protected]: To identify diffusion-weighted imaging (DWI) patterns and conspicuity discrepancies on hepatobiliary phase imaging (HBPI) to distinguish atypical hepatic abscesses from hepatic metastases.Materials and Methods: This retrospective study recruited 31 patients with 43 atypical hepatic abscesses and 32 patients with 35 hepatic metastases who underwent gadobenate dimeglumine-enhanced magnetic resonance imaging. All lesions were confirmed by pathological or clinical diagnosis. For the qualitative and quantitative analyses, the signal intensity, DWI pattern, apparent diffusion coefficient, degree of perilesional edema, perilesional hyperemia, perilesional signal on HBPI, conspicuity, size discrepancy between sequences, contrast-to-noise ratio, signal-to-noise ratio, and relative enhancement ratio on dynamic phases were independently assessed by two radiologists. Significant findings for differentiating the two groups were identified via univariate and multivariate analyses with a nomogram for predicting atypical hepatic abscesses. The interobserver agreement was also analyzed for each variable.Results: The multivariate analysis revealed that the conspicuity discrepancy (odds ratio [OR] 34.78, 95% confidence interval [CI] 2.09– 579.47, p = 0.013) and non-peripheral high signal intensity (SI) rim on DWI (OR 67.46, 95% CI 2.64, 1723.20, p = 0.011) were significant independent factors for predicting atypical hepatic abscesses. They were also shown to be high predictor points on the nomogram. When any of the set criteria were satisfied, 97.7% of atypical hepatic abscesses were correctly identified, with a specificity of 65.7%. When both criteria were combined, the specificity was up to 100%, with a sensitivity of 44.9%.Conclusion: Conspicuity discrepancy and a non-peripheral high SI rim on DWI are reliable and meaningful features that can distinguish atypical hepatic abscesses from hepatic metastases.Keywords: liver, MRI, abscess, metastasis, hepatocyte-specific contrast
