Enantioselective Catalytic Synthesis of <em>N</em>-alkylated Indoles

Abstract

During the past two decades, the interest in new methodologies for the synthesis of chiral N-functionalized indoles has grown rapidly. The review illustrates efficient applications of organocatalytic and organometallic strategies for the construction of chiral α-N-branched indoles. Both the direct functionalization of the indole core and indirect methods based on asymmetric N-alkylation of indolines, isatins and 4,7-dihydroindoles are discussed.

Keywords

• indole
• asymmetric synthesis
• organocatalysis
• transition-metal catalysis
• C-N bond formation
• enantioselective