Enhancing heating efficiency of magnetic hyperthermia using pulsed magnetic fields

Abstract

We investigated the magnetization response and heat generation of magnetic particles exposed to high-speed pulsed magnetic fields (PMF) during magnetic hyperthermia cancer treatment. The magnetization measurements exhibited an asymmetric change in the shape of the hysteresis loop, attributable to the rapid and substantial changes in the short-duration PMF (75 mT/μs). We propose a novel parameter to evaluate heat efficiency. The parameter considered disparities in waveforms and served as a valuable metric for evaluating the effectiveness of heat production. Our findings affirmed a substantial enhancement in heat efficiency with the application of PMF. Furthermore, the heat generation stemming from the magnetic energy dissipation within the PMF exhibited direct proportionality to the square of the field amplitude. The heat efficiency is fourfold higher than that generated by conventional waveform.