<i>Tisochrysis lutea</i> F&M-M36 Mitigates Risk Factors of Metabolic Syndrome and Promotes Visceral Fat Browning through β3-Adrenergic Receptor/UCP1 Signaling

Mario D’Ambrosio; Elisabetta Bigagli; Lorenzo Cinci; Manuela Gencarelli; Sofia Chioccioli; Natascia Biondi; Liliana Rodolfi; Alberto Niccolai; Francesca Zambelli; Annunziatina Laurino; Laura Raimondi; Mario R. Tredici; Cristina Luceri

doi:10.3390/md21050303

Marine Drugs (May 2023)

<i>Tisochrysis lutea</i> F&M-M36 Mitigates Risk Factors of Metabolic Syndrome and Promotes Visceral Fat Browning through β3-Adrenergic Receptor/UCP1 Signaling

Mario D’Ambrosio,
Elisabetta Bigagli,
Lorenzo Cinci,
Manuela Gencarelli,
Sofia Chioccioli,
Natascia Biondi,
Liliana Rodolfi,
Alberto Niccolai,
Francesca Zambelli,
Annunziatina Laurino,
Laura Raimondi,
Mario R. Tredici,
Cristina Luceri

Affiliations

Mario D’Ambrosio: Department of NEUROFARBA, Section of Pharmacology and Toxicology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
Elisabetta Bigagli: Department of NEUROFARBA, Section of Pharmacology and Toxicology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
Lorenzo Cinci: Department of NEUROFARBA, Section of Pharmacology and Toxicology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
Manuela Gencarelli: Department of NEUROFARBA, Section of Pharmacology and Toxicology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
Sofia Chioccioli: Department of NEUROFARBA, Section of Pharmacology and Toxicology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
Natascia Biondi: Department of Agriculture, Food, Environment and Forestry (DAGRI), University of Florence, Piazzale delle Cascine 18, 50144 Florence, Italy
Liliana Rodolfi: Department of Agriculture, Food, Environment and Forestry (DAGRI), University of Florence, Piazzale delle Cascine 18, 50144 Florence, Italy
Alberto Niccolai: Department of Agriculture, Food, Environment and Forestry (DAGRI), University of Florence, Piazzale delle Cascine 18, 50144 Florence, Italy
Francesca Zambelli: Department of NEUROFARBA, Section of Pharmacology and Toxicology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
Annunziatina Laurino: Department of NEUROFARBA, Section of Pharmacology and Toxicology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
Laura Raimondi: Department of NEUROFARBA, Section of Pharmacology and Toxicology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
Mario R. Tredici: Department of Agriculture, Food, Environment and Forestry (DAGRI), University of Florence, Piazzale delle Cascine 18, 50144 Florence, Italy
Cristina Luceri: Department of NEUROFARBA, Section of Pharmacology and Toxicology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy

DOI: https://doi.org/10.3390/md21050303
Journal volume & issue: Vol. 21, no. 5
p. 303

Abstract

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Pre-metabolic syndrome (pre-MetS) may represent the best transition phase to start treatments aimed at reducing cardiometabolic risk factors of MetS. In this study, we investigated the effects of the marine microalga Tisochrysis lutea F&M-M36 (T. lutea) on cardiometabolic components of pre-MetS and its underlying mechanisms. Rats were fed a standard (5% fat) or a high-fat diet (20% fat) supplemented or not with 5% of T. lutea or fenofibrate (100 mg/Kg) for 3 months. Like fenofibrate, T. lutea decreased blood triglycerides (p p p p T. lutea did not increase liver weight and steatosis, reduced renal fat (p p p T. lutea, but not fenofibrate, increased the β3-adrenergic receptor (β3ADR) (p p p p T. lutea up-regulated energy-metabolism-related genes and down-regulated inflammatory and autophagy pathways. The multitarget activity of T. lutea suggests that this microalga could be useful in mitigating risk factors of MetS.

Published in Marine Drugs

ISSN: 1660-3397 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: http://www.mdpi.com/journal/marinedrugs

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