Subtype-specific collaborative transcription factor networks are promoted by OCT4 in the progression of prostate cancer

Ken-ichi Takayama; Takeo Kosaka; Takashi Suzuki; Hiroshi Hongo; Mototsugu Oya; Tetsuya Fujimura; Yutaka Suzuki; Satoshi Inoue

doi:10.1038/s41467-021-23974-4

Nature Communications (Jun 2021)

Subtype-specific collaborative transcription factor networks are promoted by OCT4 in the progression of prostate cancer

Ken-ichi Takayama,
Takeo Kosaka,
Takashi Suzuki,
Hiroshi Hongo,
Mototsugu Oya,
Tetsuya Fujimura,
Yutaka Suzuki,
Satoshi Inoue

Affiliations

Ken-ichi Takayama: Department of Systems Aging Science and Medicine, Tokyo Metropolitan Institute of Gerontology
Takeo Kosaka: Department of Urology, Keio University School of Medicine
Takashi Suzuki: Department of Pathology and Histotechnology, Tohoku University Graduate School of Medicine
Hiroshi Hongo: Department of Urology, Keio University School of Medicine
Mototsugu Oya: Department of Urology, Keio University School of Medicine
Tetsuya Fujimura: Department of Urology, Jichi Medical University
Yutaka Suzuki: Department of Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo
Satoshi Inoue: Department of Systems Aging Science and Medicine, Tokyo Metropolitan Institute of Gerontology

DOI: https://doi.org/10.1038/s41467-021-23974-4
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 16

Abstract

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Transcription factors (TFs) often form distinct networks to regulate transcriptional program during cancer progression. Here the authors show that OCT4 is a common transcriptional factor in two types of advanced PC and as such, OCT4 accelerates a TF complex formation with the FOXA1/AR in castration-resistant PC and NRF1 in neuroendocrine PC.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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