Overexpression of endophilin A1 exacerbates synaptic alterations in a mouse model of Alzheimer’s disease

Qing Yu; Yongfu Wang; Fang Du; Shijun Yan; Gang Hu; Nicola Origlia; Grazia Rutigliano; Qinru Sun; Haiyang Yu; James Ainge; Shi Fang Yan; Frank Gunn-Moore; Shirley ShiDu Yan

doi:10.1038/s41467-018-04389-0

Nature Communications (Jul 2018)

Overexpression of endophilin A1 exacerbates synaptic alterations in a mouse model of Alzheimer’s disease

Qing Yu,
Yongfu Wang,
Fang Du,
Shijun Yan,
Gang Hu,
Nicola Origlia,
Grazia Rutigliano,
Qinru Sun,
Haiyang Yu,
James Ainge,
Shi Fang Yan,
Frank Gunn-Moore,
Shirley ShiDu Yan

Affiliations

Qing Yu: Department of Pharmacology and Toxicology and Higuchi Bioscience Center, University of Kansas
Yongfu Wang: Department of Pharmacology and Toxicology and Higuchi Bioscience Center, University of Kansas
Fang Du: Department of Pharmacology and Toxicology and Higuchi Bioscience Center, University of Kansas
Shijun Yan: Department of Pharmacology and Toxicology and Higuchi Bioscience Center, University of Kansas
Gang Hu: Department of Pharmacology and Toxicology and Higuchi Bioscience Center, University of Kansas
Nicola Origlia: CNR, Institute of Neuroscience
Grazia Rutigliano: CNR, Institute of Neuroscience
Qinru Sun: Department of Pharmacology and Toxicology and Higuchi Bioscience Center, University of Kansas
Haiyang Yu: State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University
James Ainge: School of Psychology and Neuroscience, University of St Andrews
Shi Fang Yan: Department of Pharmacology and Toxicology and Higuchi Bioscience Center, University of Kansas
Frank Gunn-Moore: School of Biology, Medical and Biological Sciences Building, University of St Andrews
Shirley ShiDu Yan: Department of Pharmacology and Toxicology and Higuchi Bioscience Center, University of Kansas

DOI: https://doi.org/10.1038/s41467-018-04389-0
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 14

Abstract

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Endophilin A1 protein is known to be elevated in Alzheimer’s disease (AD). Here the authors show that endophilin A1 overexpression exacerbates synaptic deficits in a mouse model of AD.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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