Virology Journal (Oct 2024)

Genomic analysis of an acute gastroenteritis outbreak caused by rotavirus C in Hebei, China

  • Kaiying Wang,
  • Yun Wang,
  • Lang Yang,
  • Jinhui Li,
  • Peihan Li,
  • Chaojie Yang,
  • Leili Jia,
  • Shaofu Qiu,
  • Hongbin Song,
  • Peng Li

DOI
https://doi.org/10.1186/s12985-024-02486-9
Journal volume & issue
Vol. 21, no. 1
pp. 1 – 7

Abstract

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Abstract Rotavirus group C is an important cause of sporadic cases and outbreaks of gastroenteritis worldwide. Whole-Genome sequences of human rotavirus C (RVC) in public databases are limited. We performed genome sequencing to analyze a RVC outbreak of acute gastroenteritis in China. Samples from 22 patients were screened for pathogens using RT-PCR, and six samples were positive for rotavirus. Whole-Genome sequencing analysis showed that the outbreak strain SJZ217 belongs to the G4-P[2]-I2-R2-C2-M3-A2-N2-T2-E2-H2 genotype and shares almost identical genomic sequences with Chungnam isolated in Korea. Phylogenetic analysis revealed strain SJZ217 also fell into a cluster with rotavirus C strains from Japan and Europe. Reassortment in the VP4 fragment was observed. These results helped to understand the genetic diversity and possible spread of RVC strains.

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