Current Chemistry Letters (Jan 2013)

Synthesis of new heterocyclic compounds using 2-(4,7-dichloro-3,3-dimethyl-indolin-2-ylidene)malonaldehyde

  • Razieh Mohammadnejad Aghdam,
  • Mehdi M. Baradaran,
  • Arash Afghan

Journal volume & issue
Vol. 2, no. 1
pp. 13 – 20

Abstract

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1-(2,5-Dichlorophenyl)hydrazine was converted via Fischer synthesis with isopropylmethylketone into 4,7-dichloro-2,3,3-trimethyl-3H-indole. Exposure of the indolenine to the vilsmeier reagent produced amino methylene malondialdehyde which reacted with hydrazine, arylhydrazine, urea, cyanoacetamide and thiourea to give pyrazols, pyrimidones and thiopyrimidone, respectively.

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