Structural mechanism of BRD4-NUT and p300 bipartite interaction in propagating aberrant gene transcription in chromatin in NUT carcinoma

Di Yu; Yingying Liang; Claudia Kim; Anbalagan Jaganathan; Donglei Ji; Xinye Han; Xuelan Yang; Yanjie Jia; Ruirui Gu; Chunyu Wang; Qiang Zhang; Ka Lung Cheung; Ming-Ming Zhou; Lei Zeng

doi:10.1038/s41467-023-36063-5

Nature Communications (Jan 2023)

Structural mechanism of BRD4-NUT and p300 bipartite interaction in propagating aberrant gene transcription in chromatin in NUT carcinoma

Di Yu,
Yingying Liang,
Claudia Kim,
Anbalagan Jaganathan,
Donglei Ji,
Xinye Han,
Xuelan Yang,
Yanjie Jia,
Ruirui Gu,
Chunyu Wang,
Qiang Zhang,
Ka Lung Cheung,
Ming-Ming Zhou,
Lei Zeng

Affiliations

Di Yu: Bethune Institute of Epigenetic Medicine, The First Hospital of Jilin University
Yingying Liang: Bethune Institute of Epigenetic Medicine, The First Hospital of Jilin University
Claudia Kim: Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai
Anbalagan Jaganathan: Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai
Donglei Ji: Bethune Institute of Epigenetic Medicine, The First Hospital of Jilin University
Xinye Han: Bethune Institute of Epigenetic Medicine, The First Hospital of Jilin University
Xuelan Yang: Bethune Institute of Epigenetic Medicine, The First Hospital of Jilin University
Yanjie Jia: Bethune Institute of Epigenetic Medicine, The First Hospital of Jilin University
Ruirui Gu: Bethune Institute of Epigenetic Medicine, The First Hospital of Jilin University
Chunyu Wang: State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University
Qiang Zhang: Bethune Institute of Epigenetic Medicine, The First Hospital of Jilin University
Ka Lung Cheung: Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai
Ming-Ming Zhou: Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai
Lei Zeng: Bethune Institute of Epigenetic Medicine, The First Hospital of Jilin University

DOI: https://doi.org/10.1038/s41467-023-36063-5
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 16

Abstract

Read online

BRD4-NUT’s bipartite binding and activation of p300 in NUT carcinoma nucleates a feed-forward spread of histone hyperacetylation and chromatin condensation that sustains aberrant pro-proliferation gene transcription and perpetual tumor cell growth.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal