Pathophysiological rationale for the results of atherogenic dyslipidemia simulation in rats

Abstract

The article presents the pathophysiological assessment of the results of atherogenic dyslipidemia simulation in Wistar rats. Dyslipidemia was followed by 24 % increase of triglyceride and 19 % raise of total cholesterol in blood, while the atherogenic cholesterol of low density lipoproteins increased by 39 %, and the content of anti-atherogenic cholesterol of high density lipoproteins decreased by 21 %. Furthermore, the level of modified low density lipoproteins in the blood increased by 1.8 times. On the background of lipid storage disorder the rats of the experimental group showed the signs of endothelial dysfunction: circulating endothelial cell number increased by 1.9 times, proinflammatory cytokines interleukin-1beta (IL-1ß), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-a) increased by 21, 18 and 16 % respectively, high-sensitivity C-reactive protein (hsCRP) concentration - by 2.2 times, and fibrinogen concentration - by 17 %.

Keywords

• atherogenic dyslipidemia
• lipid metabolism
• endothelial dysfunction