Expression and clinical significance of phosphorylated FGFR1Y654 in esophageal squamous cell carcinoma

Abstract

Objective To explore the relationship between p-FGFR1Y654 expression and clinical pathological characteristics of esophageal squamous cell carcinoma patients and its prognostic value. Methods Tumor tissue samples from 103 cases of esophageal squamous cell carcinoma and 58 normal esophageal tissues were surgically collected in the General Hospital of Western Theater between January 2017 and July 2020. The expression of p-FGFR1Y654 in the tissues was detected using immunohistochemical assay, and its correlation with relevant clinicopathological parameters and prognosis was analyzed. Results The expression of p-FGFR1Y654 in esophageal squamous cell carcinoma tissues was significantly higher than that in normal tissue (P<0.01). Its expression level was closely related to overall survival (OS, P<0.05), but not related to age, gender, tumor stage or tumor size. Multivariate COX regression analysis showed that N-stage was identified as an independent prognostic factor for recurrence free survival (RFS) in esophageal squamous cell carcinoma patients. Survival analysis indicated that patients with low expression of p-FGFR1Y654 had significantly higher RFS and OS than those with high expression (P=0.032, 95%CI: 1.08~4.65; P=0.004, 95%CI: 2.14~11.51). Conclusion p-FGFR1Y654 is highly expressed in esophageal squamous cell carcinoma tissue, and is associated with poor prognosis in these patients. p-FGFR1Y654 may be a potential therapeutic target for esophageal squamous cell carcinoma.

Keywords

• esophageal squamous cell carcinoma
• p-fgfr1y654
• prognosis
• overall survival
• recurrence free survival