Adenosine triphosphate-activated prodrug system for on-demand bacterial inactivation and wound disinfection

Yuhao Weng; Huihong Chen; Xiaoqian Chen; Huilin Yang; Chia-Hung Chen; Hongliang Tan

doi:10.1038/s41467-022-32453-3

Nature Communications (Aug 2022)

Adenosine triphosphate-activated prodrug system for on-demand bacterial inactivation and wound disinfection

Yuhao Weng,
Huihong Chen,
Xiaoqian Chen,
Huilin Yang,
Chia-Hung Chen,
Hongliang Tan

Affiliations

Yuhao Weng: National Engineering Research Center for Carbohydrate Synthesis/Key Lab of Fluorine and Silicon for Energy Materials and Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Jiangxi Normal University
Huihong Chen: National Engineering Research Center for Carbohydrate Synthesis/Key Lab of Fluorine and Silicon for Energy Materials and Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Jiangxi Normal University
Xiaoqian Chen: National Engineering Research Center for Carbohydrate Synthesis/Key Lab of Fluorine and Silicon for Energy Materials and Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Jiangxi Normal University
Huilin Yang: College of Life Science, Jiangxi Normal University
Chia-Hung Chen: Department of Biomedical Engineering, City University of Hong Kong
Hongliang Tan: National Engineering Research Center for Carbohydrate Synthesis/Key Lab of Fluorine and Silicon for Energy Materials and Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Jiangxi Normal University

DOI: https://doi.org/10.1038/s41467-022-32453-3
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 13

Abstract

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Prodrugs are increasingly promising in tackling bacterial resistance and efficacy of treatment. Here, the authors encapsulated horseradish peroxidase and zeolitic imidazolate framework-8 loaded with indole-3-acetic acid in polyacrylamide hydrogel microspheres for ATP-activated wound disinfection.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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