Hazard assessment of health effects of Gardenia Yellow

Abstract

ObjectiveHazard assessment of gardenia yellow were performed based on the existing toxicological data.MethodsThe systematic literature searches (SLS) was used to collect toxicological data. Then, the reference dose method was employed to calculate the key toxic effects according to the results of subchronic toxicity test.ResultsCrocin is the main components of gardenia yellow, and no special toxicity has been found, but its toxic target organs may be liver and kidney . Geniposide is the main toxic component and has obvious hepatorenal toxicity. The NOAEL of gardenia yellow is 0.5 g/kg BW. The BMDL10 with nephrotoxicity as the key end point is calculated as 0.46 g/kg BW by reference dose method.ConclusionRenal tubular epithelial cytopigmentation is the sensitive toxic effect of gardenia yellow. This study can provide a basis for further population intake risk assessment.

Keywords

• gardenia yellow
• hazard assessment
• reference dose method