Lkb1 deficiency confers glutamine dependency in polycystic kidney disease

Ebony M. Flowers; Jessica Sudderth; Lauren Zacharias; Glenda Mernaugh; Roy Zent; Ralph J. DeBerardinis; Thomas J. Carroll

doi:10.1038/s41467-018-03036-y

Nature Communications (Feb 2018)

Lkb1 deficiency confers glutamine dependency in polycystic kidney disease

Ebony M. Flowers,
Jessica Sudderth,
Lauren Zacharias,
Glenda Mernaugh,
Roy Zent,
Ralph J. DeBerardinis,
Thomas J. Carroll

Affiliations

Ebony M. Flowers: Departments of Molecular Biology and Internal Medicine, UT Southwestern Medical Center
Jessica Sudderth: Children’s Medical Center Research Institute at UTSW, Eugene McDermott Center for Human Growth & Development, Department of Pediatrics, UT Southwestern Medical Center
Lauren Zacharias: Children’s Medical Center Research Institute at UTSW, Eugene McDermott Center for Human Growth & Development, Department of Pediatrics, UT Southwestern Medical Center
Glenda Mernaugh: Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center
Roy Zent: Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center
Ralph J. DeBerardinis: Children’s Medical Center Research Institute at UTSW, Eugene McDermott Center for Human Growth & Development, Department of Pediatrics, UT Southwestern Medical Center
Thomas J. Carroll: Departments of Molecular Biology and Internal Medicine, UT Southwestern Medical Center

DOI: https://doi.org/10.1038/s41467-018-03036-y
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 11

Abstract

Read online

Polycystic kidney disease (PKD) is characterized by the formation of large fluid-filled cysts. Here Flowers and colleagues show that loss of Lkb1, downregulated in PKD, renders kidney cells dependent on glutamine for growth, and suggest that inhibition of glutamine metabolism may prevent cyst development in PKD.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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