Association between coronary artery disease and clinical outcome in cancer patients: A propensity score matching analysis

Zengfa Huang; Tao Li; Shan Zhang; Bei Jiang; Mei Li; Beibei Cao; Hongfeng Zhang; Zhiqiang Zhou; Zheng Huang; Xiang Wang

Heliyon (Mar 2024)

Association between coronary artery disease and clinical outcome in cancer patients: A propensity score matching analysis

Zengfa Huang,
Tao Li,
Shan Zhang,
Bei Jiang,
Mei Li,
Beibei Cao,
Hongfeng Zhang,
Zhiqiang Zhou,
Zheng Huang,
Xiang Wang

Affiliations

Zengfa Huang: Department of Radiology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430014, China
Tao Li: Department of Radiology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430014, China
Shan Zhang: Department of Radiology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430014, China
Bei Jiang: Department of Radiology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430014, China
Mei Li: Department of Community Health, Wuhan Hanyang Center For Disease Prevention and Control, Wuhan, 430050, China
Beibei Cao: Department of Community Health, Wuhan Hanyang Center For Disease Prevention and Control, Wuhan, 430050, China
Hongfeng Zhang: Department of Pathology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430014, China
Zhiqiang Zhou: Department of Anesthesiology and Pain Medicine, Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, and Wuhan Clinical Research Center for Geriatric Anesthesia, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China; Corresponding author. Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Qiaokou, Wuhan, Hubei, 430030, China.
Zheng Huang: Department of Pathology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430014, China; Corresponding author. Department of Pathology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, 26 Shengli Avenue, Jiangan, Wuhan, Hubei, 430014, China.
Xiang Wang: Department of Radiology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430014, China; Corresponding author. Department of Radiology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, 26 Shengli Avenue, Jiangan, Wuhan, Hubei, 430014, China.

Journal volume & issue: Vol. 10, no. 6
p. e28262

Abstract

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Objective: The aim of this study was to evaluate the prognostic value of coronary artery disease (CAD) detected by coronary computed tomography angiography (CTA) to predict the risk of all-cause mortality in cancer patients in a propensity score matching (PSM) analysis. Methods: A total of 331 patients who previously had cancer and underwent coronary CTA from January 2015 to December 2019 were included. Multivariate Cox proportional hazards regression analysis and propensity-score matching analysis were performed. The primary endpoint was all-cause of mortality. Results: In total, 125 with CAD and 206 with no CAD during a median follow-up of 3.3 years were included in this study. After PSM, age (HR, 1.040; 95%CI, 1.001–1.081; p = 0.014) and CAD (HR, 2.164; 95%CI, 1.057–4.430; p = 0.035) remained significant factors for all-cause mortality. Conclusion: CAD evaluated by coronary CTA was found to be at higher risk for all-cause mortality in cancer patients. Due to the retrospective design and lack of information on some medical history and treatments, especially immune checkpoint inhibitors, a large-scale prospective study is needed to further determine the prognostic value of coronary CTA in cancer patients.

Published in Heliyon

ISSN: 2405-8440 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Science: Science (General); Social Sciences: Social sciences (General)
Website: https://www.cell.com/heliyon/home

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