Antimicrobial Resistance and Infection Control (Sep 2023)
Staphylococcus aureus surgical site infection rates in 5 European countries
- Sibylle C. Mellinghoff,
- Caroline Bruns,
- Markus Albertsmeier,
- Juliane Ankert,
- Louis Bernard,
- Sofia Budin,
- Camille Bataille,
- Annika Y. Classen,
- Florian B. Cornely,
- Elodie Couvé-Deacon,
- Maria Fernandez Ferrer,
- Jesús Fortún,
- Alicia Galar,
- Eva Grill,
- Thomas Guimard,
- Jürgen A. Hampl,
- Sebastian Wingen-Heimann,
- Juan P. Horcajada,
- Felix Köhler,
- Carolin Koll,
- Joan Mollar,
- Patricia Muñoz,
- Mathias W. Pletz,
- Jule Rutz,
- Jon Salmanton-García,
- Harald Seifert,
- Ferdinand Serracino-Inglott,
- Alex Soriano,
- Jannik Stemler,
- Janne J. Vehreschild,
- Tim O. Vilz,
- Jan-Hendrik Naendrup,
- Oliver A. Cornely,
- Blasius J. Liss
Affiliations
- Sibylle C. Mellinghoff
- Department I for Internal Medicine, Excellence Centre for Medical Mycology (ECMM), University Hospital Cologne
- Caroline Bruns
- Department I for Internal Medicine, Excellence Centre for Medical Mycology (ECMM), University Hospital Cologne
- Markus Albertsmeier
- Department of General, Visceral and Transplantation Surgery, LMU University Hospital, Ludwig-Maximilians-Universität Munich
- Juliane Ankert
- Institute of Infectious Diseases and Infection Control, University Hospital Jena
- Louis Bernard
- Service de Médecine Interne et Maladies Infectieuses, Centre Hospitalier Régional Universitaire de Tours
- Sofia Budin
- Department I for Internal Medicine, Excellence Centre for Medical Mycology (ECMM), University Hospital Cologne
- Camille Bataille
- INSERM, CHU Limoges, UMR 1092, Université Limoges
- Annika Y. Classen
- Department I for Internal Medicine, Excellence Centre for Medical Mycology (ECMM), University Hospital Cologne
- Florian B. Cornely
- Department I for Internal Medicine, Excellence Centre for Medical Mycology (ECMM), University Hospital Cologne
- Elodie Couvé-Deacon
- INSERM, CHU Limoges, UMR 1092, Université Limoges
- Maria Fernandez Ferrer
- Department of Infectious Diseases, Hospital del Mar, Institut Hospital del Mar d’Investigacions Mèdiques (IMIM), Universitat Pompeu Fabra
- Jesús Fortún
- Infectious Diseases Department, CIBERINFEC, Hospital Ramón y Cajal
- Alicia Galar
- Department of Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón
- Eva Grill
- Institute for Medical Information Processing, Biometrics and Epidemiology, Ludwig-Maximilians-Universität München (LMU) Munich
- Thomas Guimard
- Service de Médecine Post-Urgence, CH Départemental de Vendée
- Jürgen A. Hampl
- Faculty of Medicine and University Hospital Cologne, Center of Neurosurgery, Department of General Neurosurgery, University of Cologne
- Sebastian Wingen-Heimann
- Department I for Internal Medicine, Excellence Centre for Medical Mycology (ECMM), University Hospital Cologne
- Juan P. Horcajada
- Department of Infectious Diseases, Hospital del Mar, Institut Hospital del Mar d’Investigacions Mèdiques (IMIM), Universitat Pompeu Fabra
- Felix Köhler
- Faculty of Medicine and University Hospital Cologne, Translational Research, Cologne Excellence Cluster On Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne
- Carolin Koll
- Department I for Internal Medicine, Excellence Centre for Medical Mycology (ECMM), University Hospital Cologne
- Joan Mollar
- Preventive Medicine Department, La Fe University and Polytechnic Hospital
- Patricia Muñoz
- Department of Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón
- Mathias W. Pletz
- Institute of Infectious Diseases and Infection Control, University Hospital Jena
- Jule Rutz
- Department I for Internal Medicine, Excellence Centre for Medical Mycology (ECMM), University Hospital Cologne
- Jon Salmanton-García
- Department I for Internal Medicine, Excellence Centre for Medical Mycology (ECMM), University Hospital Cologne
- Harald Seifert
- Department I for Internal Medicine, Excellence Centre for Medical Mycology (ECMM), University Hospital Cologne
- Ferdinand Serracino-Inglott
- Manchester Academic Health Science Centre, Manchester University NHS Foundation Trust
- Alex Soriano
- Department of Infectious Diseases, Clinic Barcelona, University of Barcelona, IDIBAPS, CIBERINF, Ciber in Infectious Diseases
- Jannik Stemler
- Department I for Internal Medicine, Excellence Centre for Medical Mycology (ECMM), University Hospital Cologne
- Janne J. Vehreschild
- Department I for Internal Medicine, Excellence Centre for Medical Mycology (ECMM), University Hospital Cologne
- Tim O. Vilz
- Department of Surgery, University Hospital Bonn
- Jan-Hendrik Naendrup
- Department I for Internal Medicine, Excellence Centre for Medical Mycology (ECMM), University Hospital Cologne
- Oliver A. Cornely
- Department I for Internal Medicine, Excellence Centre for Medical Mycology (ECMM), University Hospital Cologne
- Blasius J. Liss
- Department I of Internal Medicine, Helios University Hospital Wuppertal
- DOI
- https://doi.org/10.1186/s13756-023-01309-w
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 12
Abstract
Abstract Objective To determine the overall and procedure-specific incidence of surgical site infections (SSI) caused by Staphylococcus aureus (S. aureus) as well as risk factors for such across all surgical disciplines in Europe. Methods This is a retrospective cohort of patients with surgical procedures performed at 14 European centres in 2016, with a nested case–control analysis. S. aureus SSI were identified by a semi-automated crossmatching bacteriological and electronic health record data. Within each surgical procedure, cases and controls were matched using optimal propensity score matching. Results A total of 764 of 178 902 patients had S. aureus SSI (0.4%), with 86.0% of these caused by methicillin susceptible and 14% by resistant pathogens. Mean S. aureus SSI incidence was similar for all surgical specialties, while varying by procedure. Conclusions This large procedure-independent study of S. aureus SSI proves a low overall infection rate of 0.4% in this cohort. It provides proof of principle for a semi-automated approach to utilize big data in epidemiological studies of healthcare-associated infections. Trials registration The study was registered at clinicaltrials.gov under NCT03353532 (11/2017).
Keywords
