Tiam1/Rac1 complex controls Il17a transcription and autoimmunity

Ahmed T. Kurdi; Ribal Bassil; Marta Olah; Chuan Wu; Sheng Xiao; Mariko Taga; Michael Frangieh; Thomas Buttrick; William Orent; Elizabeth M. Bradshaw; Samia J. Khoury; Wassim Elyaman

doi:10.1038/ncomms13048

Nature Communications (Oct 2016)

Tiam1/Rac1 complex controls Il17a transcription and autoimmunity

Ahmed T. Kurdi,
Ribal Bassil,
Marta Olah,
Chuan Wu,
Sheng Xiao,
Mariko Taga,
Michael Frangieh,
Thomas Buttrick,
William Orent,
Elizabeth M. Bradshaw,
Samia J. Khoury,
Wassim Elyaman

Affiliations

Ahmed T. Kurdi: Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital and Harvard Medical School
Ribal Bassil: Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital and Harvard Medical School
Marta Olah: Department of Neurology, Program in Translational NeuroPsychiatric Genomics, Brigham and Women’s Hospital, Harvard Medical School, Broad Institute at Harvard University and MIT
Chuan Wu: Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital and Harvard Medical School
Sheng Xiao: Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital and Harvard Medical School
Mariko Taga: Department of Neurology, Program in Translational NeuroPsychiatric Genomics, Brigham and Women’s Hospital, Harvard Medical School, Broad Institute at Harvard University and MIT
Michael Frangieh: Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital and Harvard Medical School
Thomas Buttrick: Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital and Harvard Medical School
William Orent: Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital and Harvard Medical School
Elizabeth M. Bradshaw: Department of Neurology, Program in Translational NeuroPsychiatric Genomics, Brigham and Women’s Hospital, Harvard Medical School, Broad Institute at Harvard University and MIT
Samia J. Khoury: Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital and Harvard Medical School
Wassim Elyaman: Department of Neurology, Program in Translational NeuroPsychiatric Genomics, Brigham and Women’s Hospital, Harvard Medical School, Broad Institute at Harvard University and MIT

DOI: https://doi.org/10.1038/ncomms13048
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 14

Abstract

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Tiam1 is a guanine nucleotide exchange factor for the Rho-family GTPase Rac1. Here, the authors show that nuclear Tiam1 and Rac1 bind to RORγt on the IL-17 promoter, activating its transcription, and that inhibiting Tiam1/Rac1 is beneficial in a mouse model of autoimmunity.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal