Nature Communications (Jun 2017)
IL-21-mediated reversal of NK cell exhaustion facilitates anti-tumour immunity in MHC class I-deficient tumours
- Hyungseok Seo,
- Insu Jeon,
- Byung-Seok Kim,
- Myunghwan Park,
- Eun-Ah Bae,
- Boyeong Song,
- Choong-Hyun Koh,
- Kwang-Soo Shin,
- Il-Kyu Kim,
- Kiyoung Choi,
- Taegwon Oh,
- Jiyoun Min,
- Byung Soh Min,
- Yoon Dae Han,
- Suk-Jo Kang,
- Sang Joon Shin,
- Yeonseok Chung,
- Chang-Yuil Kang
Affiliations
- Hyungseok Seo
- Department of Molecular Medicine and Biopharmaceutical Sciences, Laboratory of Immunology, Graduate School of Convergence Science and Technology, Seoul National University
- Insu Jeon
- Department of Molecular Medicine and Biopharmaceutical Sciences, Laboratory of Immunology, Graduate School of Convergence Science and Technology, Seoul National University
- Byung-Seok Kim
- Laboratory of Immune Regulation, Research Institute of Pharmaceutical Science, College of Pharmacy, Seoul National University
- Myunghwan Park
- Department of Molecular Medicine and Biopharmaceutical Sciences, Laboratory of Immunology, Graduate School of Convergence Science and Technology, Seoul National University
- Eun-Ah Bae
- Department of Molecular Medicine and Biopharmaceutical Sciences, Laboratory of Immunology, Graduate School of Convergence Science and Technology, Seoul National University
- Boyeong Song
- Department of Molecular Medicine and Biopharmaceutical Sciences, Laboratory of Immunology, Graduate School of Convergence Science and Technology, Seoul National University
- Choong-Hyun Koh
- Laboratory of Immunology, Research Institute of Pharmaceutical Science, College of Pharmacy Seoul National University
- Kwang-Soo Shin
- Laboratory of Immunology, Research Institute of Pharmaceutical Science, College of Pharmacy Seoul National University
- Il-Kyu Kim
- Department of Molecular Medicine and Biopharmaceutical Sciences, Laboratory of Immunology, Graduate School of Convergence Science and Technology, Seoul National University
- Kiyoung Choi
- Cellid, Inc.
- Taegwon Oh
- Cellid, Inc.
- Jiyoun Min
- Department of Biological Science, Korea Advanced Institute of Science and Technology
- Byung Soh Min
- Department of Surgery, Yonsei University College of Medicine
- Yoon Dae Han
- Department of Surgery, Yonsei University College of Medicine
- Suk-Jo Kang
- Department of Biological Science, Korea Advanced Institute of Science and Technology
- Sang Joon Shin
- Department of Internal Medicine, Yonsei University College of Medicine
- Yeonseok Chung
- Laboratory of Immune Regulation, Research Institute of Pharmaceutical Science, College of Pharmacy, Seoul National University
- Chang-Yuil Kang
- Department of Molecular Medicine and Biopharmaceutical Sciences, Laboratory of Immunology, Graduate School of Convergence Science and Technology, Seoul National University
- DOI
- https://doi.org/10.1038/ncomms15776
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 14
Abstract
Loss of major histocompatibility complex MHC-I expression contributes to cancer immune evasion. Here, the authors show that, in both mice and humans, MHC-I downregulation is associated with the induction of NK-cell exhaustion and that IL-21 restores NK-cell function and inhibits tumours progression.
