Nature Communications (Jan 2018)
Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells
- Brent D. G. Page,
- Nicholas C. K. Valerie,
- Roni H. G. Wright,
- Olov Wallner,
- Rebecka Isaksson,
- Megan Carter,
- Sean G. Rudd,
- Olga Loseva,
- Ann-Sofie Jemth,
- Ingrid Almlöf,
- Jofre Font-Mateu,
- Sabin Llona-Minguez,
- Pawel Baranczewski,
- Fredrik Jeppsson,
- Evert Homan,
- Helena Almqvist,
- Hanna Axelsson,
- Shruti Regmi,
- Anna-Lena Gustavsson,
- Thomas Lundbäck,
- Martin Scobie,
- Kia Strömberg,
- Pål Stenmark,
- Miguel Beato,
- Thomas Helleday
Affiliations
- Brent D. G. Page
- Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet
- Nicholas C. K. Valerie
- Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet
- Roni H. G. Wright
- Centre de Regulació Genòmica (CRG), Barcelona Institute for Science and Technology
- Olov Wallner
- Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet
- Rebecka Isaksson
- Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet
- Megan Carter
- Department of Biochemistry and Biophysics, Stockholm University
- Sean G. Rudd
- Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet
- Olga Loseva
- Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet
- Ann-Sofie Jemth
- Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet
- Ingrid Almlöf
- Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet
- Jofre Font-Mateu
- Centre de Regulació Genòmica (CRG), Barcelona Institute for Science and Technology
- Sabin Llona-Minguez
- Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet
- Pawel Baranczewski
- Uppsala University Drug Optimization and Pharmaceutical Profiling Platform, Department of Pharmacy, Uppsala University
- Fredrik Jeppsson
- Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet
- Evert Homan
- Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet
- Helena Almqvist
- Chemical Biology Consortium Sweden, Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet
- Hanna Axelsson
- Chemical Biology Consortium Sweden, Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet
- Shruti Regmi
- Chemical Biology Consortium Sweden, Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet
- Anna-Lena Gustavsson
- Chemical Biology Consortium Sweden, Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet
- Thomas Lundbäck
- Chemical Biology Consortium Sweden, Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet
- Martin Scobie
- Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet
- Kia Strömberg
- Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet
- Pål Stenmark
- Department of Biochemistry and Biophysics, Stockholm University
- Miguel Beato
- Centre de Regulació Genòmica (CRG), Barcelona Institute for Science and Technology
- Thomas Helleday
- Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet
- DOI
- https://doi.org/10.1038/s41467-017-02293-7
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 14
Abstract
NUDIX hydrolases are an important family of nucleotide-metabolizing enzymes. Here, the authors identify potent, small molecule inhibitors of NUDT5, which is implicated in ADP-ribose and 8-oxo-guanine metabolism, and confirm its role in gene regulation and proliferation in breast cancer cells.
