Nature Communications (Feb 2018)
BMI1 regulates androgen receptor in prostate cancer independently of the polycomb repressive complex 1
- Sen Zhu,
- Dongyu Zhao,
- Lin Yan,
- Weihua Jiang,
- Jung-Sun Kim,
- Bingnan Gu,
- Qipeng Liu,
- Rui Wang,
- Bo Xia,
- Jonathan C. Zhao,
- Gang Song,
- Wenyi Mi,
- Rong-Fu Wang,
- Xiaobing Shi,
- Hung-Ming Lam,
- Xuesen Dong,
- Jindan Yu,
- Kaifu Chen,
- Qi Cao
Affiliations
- Sen Zhu
- Center for Inflammation and Epigenetics, Houston Methodist Research Institute
- Dongyu Zhao
- Center for Cardiovascular Regeneration, Houston Methodist Research Institute
- Lin Yan
- Center for Inflammation and Epigenetics, Houston Methodist Research Institute
- Weihua Jiang
- Center for Inflammation and Epigenetics, Houston Methodist Research Institute
- Jung-Sun Kim
- Center for Inflammation and Epigenetics, Houston Methodist Research Institute
- Bingnan Gu
- Center for Inflammation and Epigenetics, Houston Methodist Research Institute
- Qipeng Liu
- Center for Inflammation and Epigenetics, Houston Methodist Research Institute
- Rui Wang
- Center for Inflammation and Epigenetics, Houston Methodist Research Institute
- Bo Xia
- Center for Cardiovascular Regeneration, Houston Methodist Research Institute
- Jonathan C. Zhao
- Division of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine
- Gang Song
- Department of Urology, Peking University First Hospital, Institute of Urology, Peking University
- Wenyi Mi
- Department of Epigenetics and Molecular Carcinogenesis, Division of Basic Science Research, The University of Texas MD Anderson Cancer Center
- Rong-Fu Wang
- Center for Inflammation and Epigenetics, Houston Methodist Research Institute
- Xiaobing Shi
- Department of Epigenetics and Molecular Carcinogenesis, Division of Basic Science Research, The University of Texas MD Anderson Cancer Center
- Hung-Ming Lam
- Department of Urology, University of Washington
- Xuesen Dong
- Vancouver Prostate Centre, Vancouver General Hospital
- Jindan Yu
- Division of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine
- Kaifu Chen
- Center for Cardiovascular Regeneration, Houston Methodist Research Institute
- Qi Cao
- Center for Inflammation and Epigenetics, Houston Methodist Research Institute
- DOI
- https://doi.org/10.1038/s41467-018-02863-3
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 13
Abstract
The polycomb group protein BMI1 is highly expressed in prostate cancer. Here, the authors demonstrate that BMI1 directly interacts with AR leading to increased AR signaling independently of PRC1 complex and that targeting BMI1 inhibits tumor growth of castration-resistant prostate cancer tumors.
