Nature Communications (Dec 2020)

An oxindole efflux inhibitor potentiates azoles and impairs virulence in the fungal pathogen Candida auris

  • Kali R. Iyer,
  • Kaddy Camara,
  • Martin Daniel-Ivad,
  • Richard Trilles,
  • Sheila M. Pimentel-Elardo,
  • Jen L. Fossen,
  • Karen Marchillo,
  • Zhongle Liu,
  • Shakti Singh,
  • José F. Muñoz,
  • Sang Hu Kim,
  • John A. Porco,
  • Christina A. Cuomo,
  • Noelle S. Williams,
  • Ashraf S. Ibrahim,
  • John E. Edwards,
  • David R. Andes,
  • Justin R. Nodwell,
  • Lauren E. Brown,
  • Luke Whitesell,
  • Nicole Robbins,
  • Leah E. Cowen

DOI
https://doi.org/10.1038/s41467-020-20183-3
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 17

Abstract

Read online

The fungal pathogen Candida auris is resistant to multiple drugs including the common antifungal fluconazole. Here, Iyer et al. identify a compound that potentiates fluconazole activity against C. auris in vitro and in vivo by inhibiting a major efflux pump and thus increasing intracellular fluconazole accumulation.