Ethanol abolishes vigilance-dependent astroglia network activation in mice by inhibiting norepinephrine release

Liang Ye; Murat Orynbayev; Xiangyu Zhu; Eunice Y. Lim; Ram R. Dereddi; Amit Agarwal; Dwight E. Bergles; Manzoor A. Bhat; Martin Paukert

doi:10.1038/s41467-020-19475-5

Nature Communications (Dec 2020)

Ethanol abolishes vigilance-dependent astroglia network activation in mice by inhibiting norepinephrine release

Liang Ye,
Murat Orynbayev,
Xiangyu Zhu,
Eunice Y. Lim,
Ram R. Dereddi,
Amit Agarwal,
Dwight E. Bergles,
Manzoor A. Bhat,
Martin Paukert

Affiliations

Liang Ye: Department of Cellular and Integrative Physiology, University of Texas Health Science Center at San Antonio
Murat Orynbayev: Department of Cellular and Integrative Physiology, University of Texas Health Science Center at San Antonio
Xiangyu Zhu: Department of Cellular and Integrative Physiology, University of Texas Health Science Center at San Antonio
Eunice Y. Lim: Department of Cellular and Integrative Physiology, University of Texas Health Science Center at San Antonio
Ram R. Dereddi: The Chica and Heinz Schaller Research Group, Institute for Anatomy and Cell Biology, Heidelberg University
Amit Agarwal: The Chica and Heinz Schaller Research Group, Institute for Anatomy and Cell Biology, Heidelberg University
Dwight E. Bergles: Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine
Manzoor A. Bhat: Department of Cellular and Integrative Physiology, University of Texas Health Science Center at San Antonio
Martin Paukert: Department of Cellular and Integrative Physiology, University of Texas Health Science Center at San Antonio

DOI: https://doi.org/10.1038/s41467-020-19475-5
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 20

Abstract

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The effects of norepinephrine on sensory processing in cortical networks are altered by recreational drugs like ethanol. The authors show that ethanol suppresses the activation of astrocytes by inhibiting norepinephrine release which may contribute to the cognitive effects of alcohol intoxication.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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