The Complexity of FGF23 Effects on Cardiomyocytes in Normal and Uremic Milieu

Andreja Figurek; Merita Rroji; Goce Spasovski

doi:10.3390/cells10051266

Cells (May 2021)

The Complexity of FGF23 Effects on Cardiomyocytes in Normal and Uremic Milieu

Andreja Figurek,
Merita Rroji,
Goce Spasovski

Affiliations

Andreja Figurek: Department of Internal Medicine, Medical Faculty, University of Banja Luka, 78000 Banja Luka, Republic of Srpska, Bosnia and Herzegovina
Merita Rroji: Department of Nephrology, Faculty of Medicine, University of Medicine Tirana, 1001 Tirana, Albania
Goce Spasovski: Department of Nephrology, Medical Faculty, University of Ss. Cyril and Methodius, 1000 Skopje, North Macedonia

DOI: https://doi.org/10.3390/cells10051266
Journal volume & issue: Vol. 10, no. 5
p. 1266

Abstract

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Fibroblast growth factor-23 (FGF23) appears to be one of the most promising biomarkers and predictors of cardiovascular risk in patients with heart disease and normal kidney function, but moreover in those with chronic kidney disease (CKD). This review summarizes the current knowledge of FGF23 mechanisms of action in the myocardium in the physiological and pathophysiological state of CKD, as well as its cross-talk to other important signaling pathways in cardiomyocytes. In this regard, current therapeutic possibilities and future perspectives are also discussed.

Published in Cells

ISSN: 2073-4409 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General): Cytology
Website: https://www.mdpi.com/journal/cells

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