npj Antimicrobials and Resistance (Oct 2024)

Phage therapy could be key to conquering persistent bacterial lung infections in children

  • Aye Mya Sithu Shein,
  • Parichart Hongsing,
  • Aisha Khatib,
  • Phatthranit Phattharapornjaroen,
  • Kazuhiko Miyanaga,
  • Longzhu Cui,
  • Kenji Shibuya,
  • Mohan Amarasiri,
  • Peter N. Monk,
  • Anthony Kicic,
  • Tanittha Chatsuwan,
  • Paul G. Higgins,
  • Shuichi Abe,
  • Dhammika Leshan Wannigama

DOI
https://doi.org/10.1038/s44259-024-00045-4
Journal volume & issue
Vol. 2, no. 1
pp. 1 – 19

Abstract

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Abstract Persistent bacterial lung infections in children lead to significant morbidity and mortality due to antibiotic resistance. In this paper, we describe how phage therapy has shown remarkable efficacy in preclinical and clinical studies, demonstrating significant therapeutic benefits through various administration routes. Ongoing trials are evaluating its safety and effectiveness against different pathogens. Advancing phage therapy through systematic studies and international collaboration could provide a viable alternative to traditional antibiotics for persistent infections.